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      Centella asiatica Leaf Extract Protects Against Indomethacin-Induced Gastric Mucosal Injury in Rats.

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          Abstract

          The present study evaluated the protective effect of Centella asiatica (gotu kola) leaf extract (CAE) against indomethacin (IND)-induced gastric mucosal injury in rats. Gastric mucosal injury was induced by the oral administration of IND to the rats after a 24 h fast. CAE (50 or 250 mg/kg) or lansoprazole (a reference drug) was orally administrated 30 min before the IND administration, and 5 h later, the stomachs were removed to quantify the lesions. Orally administered CAE significantly reduced IND-induced gastric injury. The histopathological observations (hematoxylin-eosin and Periodic acid-Schiff staining) confirmed the protection against gastric mucosal injury. Also, CAE decreased the malondialdehyde content compared to the control group. Moreover, pretreatment with CAE resulted in a significant reduction in the elevated expression of tumor necrosis factor, Cyclooxygenase (COX)-2, and inducible nitric oxide synthase. These results suggested that CAE possesses gastroprotective effects against IND-induced gastric mucosal injury, which could be attributed to its ability to inhibit lipid peroxidation and stimulate gastric mucus secretion in the rat gastric mucosa.

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          Author and article information

          Journal
          J Med Food
          Journal of medicinal food
          Mary Ann Liebert Inc
          1557-7600
          1096-620X
          Jan 2016
          : 19
          : 1
          Affiliations
          [1 ] 1 Department of New Drug Development, College of Medicine, Inha University Hospital , Incheon, Korea.
          [2 ] 2 National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorder, Inha University Hospital , Incheon, Korea.
          [3 ] 3 R&D Center , Dongkook Pharmaceutical, Seoul, Korea.
          [4 ] 4 Division of Gastroenterology and Hepatology, Inha University Hospital , Incheon, Korea.
          Article
          10.1089/jmf.2015.3464
          26469560
          79ea6c9b-06d0-46ba-9e13-09fd31207536
          History

          Centella asiatica leaf extract,gastroprotection,indomethacin,lipid peroxidation

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