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      Emergence of norovirus GII.2 and its novel recombination during the gastroenteritis outbreak in Japanese children in mid-2016.

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          Abstract

          In mid-2016, norovirus GII.2 emerged as a major cause of gastroenteritis outbreak in Japan with overall detection rate of 56.3% of norovirus cases. The differences in ORF1 and ORF2 of some norovirus GII were observed. Inter-subtype recombinants GII.Pe/GII.2, GII.P16/GII.2 and GII.P17/GII.2 were detected. Three amino acid substitutions were noted at P2 antigenic site of GII.P16/GII.2 recombinants. Furthermore, this study revealed that the current immunochromatographic kit available in Japan could be used effectively for the detection of recent GII.2 genotype.

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          Author and article information

          Journal
          Infect. Genet. Evol.
          Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
          Elsevier BV
          1567-7257
          1567-1348
          Jul 2017
          : 51
          Affiliations
          [1 ] Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
          [2 ] Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
          [3 ] Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
          [4 ] Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: ushijima-hiroshi@jcom.home.ne.jp.
          Article
          S1567-1348(17)30103-X
          10.1016/j.meegid.2017.03.020
          28336428
          79f01e4e-381c-4b0c-9c09-91965afe2615
          History

          Gastroenteritis,Japan,Norovirus,Outbreak,Recombinant
          Gastroenteritis, Japan, Norovirus, Outbreak, Recombinant

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