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Optionen des Debridements in der Therapie chronischer Wunden. Options for debridement in the therapy of chronic wounds

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Journal der Deutschen Dermatologischen Gesellschaft

Wiley

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      Growth effects of Phaenicia sericata larval extracts on fibroblasts: Mechanism for wound healing by maggot therapy

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        Degradation of extracellular matrix components by defined proteinases from the greenbottle larva Lucilia sericata used for the clinical debridement of non-healing wounds

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          Collagen-and collagen peptide-induced chemotaxis of human blood monocytes

          The ability of collagen and collagen-derived peptides to act as chemotactic stimuli was investigated by in vitro chemotaxis assays. Native human and chick skin collagen (type I) and alpha-chains obtained from purified chick skin collagen were each chemotactic for human peripheral blood monocytes. In addition, smaller peptides obtained either by digesting native collagen with bacterial collagenase or by degrading purified alpha-chains with cyanogen bromide or pepsin were also chemotactic for monocytes. In contrast, native collagen, alpha- chains, and smaller collagen-derived peptides were not chemotactic for human neutrophils. Since collagen is degraded at sites of tissue damage and inflammation, our findings suggest the possibility that such collagen-derived degradation products might directly serve as chemotactic stimuli for human peripheral blood monocytes in vivo.
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            Author and article information

            Journal
            Journal der Deutschen Dermatologischen Gesellschaft
            J Deut Dermatol Gesell
            Wiley
            1610-0379
            1610-0387
            September 2004
            September 2004
            : 2
            : 9
            : 743-751
            10.1046/j.1439-0353.2004.04053.x
            © 2004

            http://doi.wiley.com/10.1002/tdm_license_1.1

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