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      Optionen des Debridements in der Therapie chronischer Wunden. Options for debridement in the therapy of chronic wounds

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      Journal der Deutschen Dermatologischen Gesellschaft

      Wiley

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          Degradation of extracellular matrix components by defined proteinases from the greenbottle larva Lucilia sericata used for the clinical debridement of non-healing wounds

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            Growth effects of Phaenicia sericata larval extracts on fibroblasts: Mechanism for wound healing by maggot therapy

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              Collagen-and collagen peptide-induced chemotaxis of human blood monocytes

              The ability of collagen and collagen-derived peptides to act as chemotactic stimuli was investigated by in vitro chemotaxis assays. Native human and chick skin collagen (type I) and alpha-chains obtained from purified chick skin collagen were each chemotactic for human peripheral blood monocytes. In addition, smaller peptides obtained either by digesting native collagen with bacterial collagenase or by degrading purified alpha-chains with cyanogen bromide or pepsin were also chemotactic for monocytes. In contrast, native collagen, alpha- chains, and smaller collagen-derived peptides were not chemotactic for human neutrophils. Since collagen is degraded at sites of tissue damage and inflammation, our findings suggest the possibility that such collagen-derived degradation products might directly serve as chemotactic stimuli for human peripheral blood monocytes in vivo.
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                Author and article information

                Journal
                Journal der Deutschen Dermatologischen Gesellschaft
                J Deut Dermatol Gesell
                Wiley
                1610-0379
                1610-0387
                September 2004
                September 2004
                : 2
                : 9
                : 743-751
                10.1046/j.1439-0353.2004.04053.x
                © 2004

                http://doi.wiley.com/10.1002/tdm_license_1.1

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