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      Pediatric antiphospholipid syndrome

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          Abstract

          Despite its potential to cause significant morbidity in children, pediatric antiphospholipid syndrome (APS) is an understudied condition. In this review, we will cover what is known about pediatric APS epidemiology and how the clinician might approach the diagnosis of pediatric APS. We will highlight similarities and differences with the adult disease, both for primary APS and in the context of lupus. Clinical manifestations beyond thrombosis, especially neurologic and hematologic in nature, will be discussed. We will also consider what unique implications antiphospholipid antibody-positivity may have for children with lupus and for neonates born to mothers with APS. The approach to treatment will be covered, including the unique impact of APS medications on children as compared with adults. Finally, the importance of future mechanistic research is emphasized as physicians endeavor to provide the personalized care that children with APS clearly deserve.

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          Author and article information

          Journal
          Eur J Rheumatol
          Eur J Rheumatol
          European Journal of Rheumatology
          Medical Research and Education Association
          2147-9720
          2148-4279
          February 2020
          03 December 2019
          : 7
          : Suppl 1
          : S3-S12
          Affiliations
          [1 ]Division of Pediatric Rheumatology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
          [2 ]Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
          Author notes
          Address for Correspondence: Jason S. Knight; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA, E-mail: jsknight@ 123456umich.edu
          Article
          PMC7004270 PMC7004270 7004270 ejr-7-suppl1-s3
          10.5152/eurjrheum.2019.19160
          7004270
          31804173
          7a0885cc-90dc-4edf-86ea-b4a9e3427f29
          © Copyright by 2020 Medical Research and Education Association

          Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

          Categories
          Invited Review

          neonatal,lupus,pediatric,catastrophic antiphospholipid syndrome,antiphospholipid antibodies,Antiphospholipid syndrome

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