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      MORPHOLOGICAL CHANGES IN LUNGS, HEART AND LIVER CAUSED BY EXPERIMENTAL ASSOCIATED CHEST AND THIGHS TRAUMA

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          Abstract

          Background. According to preliminary results obtained, the development of hypoxemia caused by chest trauma affected lipid peroxidation stimulation leading to disruption of cell membranes structure and consequently cell death closing the ‘vicious’ circle, which in our opinion and according to the literature cause multiple organ failure. Objective. The aim of our study was to determine the features of morphological changes in cases of heart, lungs, liver injury after associated chest and both thighs trauma in rats. Methods. For histological examination the pieces of left ventricle tissues of heart, lungs and liver were used, which were fixed in 10% neutral formalin solution, dehydrated and embedded in paraffin blocks. Results. It was established that associated trauma of chest and both thighs in 1 day after the injury is accompanied by disturbances of hemodynamics in parenchymal organs due to venous congestion that occurs during the development of cardiovascular disease caused by traumatic shock. In the most severe period of maximum likelihood of complications, within 3 days, respiratory hypoxia, cardiovascular disorders, metabolic acidosis, and induced programmed cell death may develop. Conclusions. On the background of increasing pulmonary oedema (thickening of inter air sac membranes) caused by associated trauma of chest and both thighs in rats after only one day of the experiment hemodynamic changes in heart (low-blood supply of vessels in epicardium and isolated blood vessels of venous type) and liver (mainly plethora of blood vessels) were observed, which lead to morphological changes of myocardium within 3 days.

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          Author and article information

          Journal
          International Journal of Medicine and Medical Research
          Ukrmedknyha
          01 July 2017
          : 0
          : 1
          Affiliations
          [1 ] I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
          [2 ] TARAS SHEVCHENKO REGIONAL HUMANITARIAN PEDAGOGICAL ACADEMY OF KREMENETS
          6d8e229c39874b9790ba0d54310b3900
          10.11603/ijmmr.2413-6077.2017.1.7625

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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          Medicine
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