81
views
2
recommends
+1 Recommend
1 collections
    4
    shares

      To submit to the journal, please click here

      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      MORPHOLOGICAL CHANGES IN LUNGS, HEART AND LIVER CAUSED BY EXPERIMENTAL ASSOCIATED CHEST AND THIGHS TRAUMA

      Read this article at

      ScienceOpenPublisherDOAJ
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background. According to preliminary results obtained, the development of hypoxemia caused by chest trauma affected lipid peroxidation stimulation leading to disruption of cell membranes structure and consequently cell death closing the ‘vicious’ circle, which in our opinion and according to the literature cause multiple organ failure. Objective. The aim of our study was to determine the features of morphological changes in cases of heart, lungs, liver injury after associated chest and both thighs trauma in rats. Methods. For histological examination the pieces of left ventricle tissues of heart, lungs and liver were used, which were fixed in 10% neutral formalin solution, dehydrated and embedded in paraffin blocks. Results. It was established that associated trauma of chest and both thighs in 1 day after the injury is accompanied by disturbances of hemodynamics in parenchymal organs due to venous congestion that occurs during the development of cardiovascular disease caused by traumatic shock. In the most severe period of maximum likelihood of complications, within 3 days, respiratory hypoxia, cardiovascular disorders, metabolic acidosis, and induced programmed cell death may develop. Conclusions. On the background of increasing pulmonary oedema (thickening of inter air sac membranes) caused by associated trauma of chest and both thighs in rats after only one day of the experiment hemodynamic changes in heart (low-blood supply of vessels in epicardium and isolated blood vessels of venous type) and liver (mainly plethora of blood vessels) were observed, which lead to morphological changes of myocardium within 3 days.

          Related collections

          Author and article information

          Journal
          International Journal of Medicine and Medical Research
          Ukrmedknyha
          01 July 2017
          : 0
          : 1
          Affiliations
          [1 ] I. HORBACHEVSKY TERNOPIL STATE MEDICAL UNIVERSITY
          [2 ] TARAS SHEVCHENKO REGIONAL HUMANITARIAN PEDAGOGICAL ACADEMY OF KREMENETS
          Article
          6d8e229c39874b9790ba0d54310b3900
          10.11603/ijmmr.2413-6077.2017.1.7625
          7a16825e-5aae-4672-aa37-ada7592a93a6

          This work is licensed under a Creative Commons Attribution 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

          History
          Categories
          Medicine
          R

          Medicine,Pediatrics,Surgery,Dentistry,Internal medicine,Pharmacology & Pharmaceutical medicine
          trauma,lungs,morphological changes.,liver,heart

          Comments

          Comment on this article