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      Synergistic Catalysis: A Powerful Synthetic Strategy for New Reaction Development.

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          Abstract

          Synergistic catalysis is a synthetic strategy wherein both the nucleophile and the electrophile are simultaneously activated by two separate and distinct catalysts to afford a single chemical transformation. This powerful catalysis strategy leads to several benefits, specifically synergistic catalysis can (i) introduce new, previously unattainable chemical transformations, (ii) improve the efficiency of existing transformations, and (iii) create or improve catalytic enantioselectivity where stereocontrol was previously absent or challenging. This perspective aims to highlight these benefits using many of the successful examples of synergistic catalysis found in the literature.

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          Author and article information

          Journal
          Chem Sci
          Chemical science (Royal Society of Chemistry : 2010)
          2041-6520
          2041-6520
          Jan 1 2012
          : 2012
          : 3
          Affiliations
          [1 ] Merck Center for Catalysis at Princeton University, Princeton, New Jersey, 08544, USA; ; Tel: +1 609 2582254.
          Article
          NIHMS360530
          10.1039/C2SC00907B
          22518271
          7a1847f6-0791-4375-a055-09f177c9de90
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