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      Bacterial extracellular vesicles: A new way to decipher host-microbiota communications in inflammatory dermatoses.

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          Abstract

          Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, bearing integral proteins and able to carry diverse cargo outside the cell to distant sites. In microorganisms, EVs carry several types of molecules: proteins, glycoproteins, mRNAs and small RNA species, as mammalian EVs do, but also carbohydrates. Studying EVs opens a whole new world of possibilities to better understand the interplay between host and bacteria crosstalks, although there are still many questions to be answered in the field, especially when it comes to microbiota-derived EVs. In this review, we propose to summarize and analyse the current literature about bacterial EVs and possible clinical applications, through answering three main questions: (a) What are bacterial EVs? (b) What are EV impacts on skin inflammatory disease physiopathology? (iii) What are the possible and expected clinical applications of EVs to treat inflammatory skin diseases?

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          Author and article information

          Journal
          Exp Dermatol
          Experimental dermatology
          Wiley
          1600-0625
          0906-6705
          January 2020
          : 29
          : 1
          Affiliations
          [1 ] Dermatology Department, CHU Nantes, CIC 1413, CRCINA, University Nantes, Nantes, France.
          [2 ] Bacteriology Department, CHU Nantes, CRCINA, University Nantes, Nantes, France.
          Article
          10.1111/exd.14050
          31633842
          7a1dfb56-36b9-4de8-898b-f033a89435a1
          © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
          History

          cell-to-cell communication,exosomes,extracellular vesicles,microbiota,probiotics,skin microbiota

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