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      Macrophage-colony stimulating factor (CSF1) predicts breast cancer progression and mortality.

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          Abstract

          Macrophage colony-stimulating factor (CSF1), also known as colony-stimulating factor-1 (CSF1), and its receptor CSF1R have been correlated with poor prognosis in many cancer types including breast cancer. Herein, we investigated the prognostic impact of CSF1 and CSF1R expression in tumor epithelial and stromal compartments in primary breast cancer and axillary lymph node metastases. In addition, the density of CD68+ tumor-associated macrophages (TAMs) and CD3+ T-lymphocytes was examined.

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          Author and article information

          Journal
          Anticancer Res.
          Anticancer research
          1791-7530
          0250-7005
          Feb 2015
          : 35
          : 2
          Affiliations
          [1 ] Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway Department of Medical Biology, The Arctic University of Norway, Tromsø, Norway elin.richardsen@unn.no.
          [2 ] Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway.
          [3 ] Department of Neurology and Clinical Neurophysiology, University Hospital of Northern Norway, Tromsø, Norway Department of Clinical Medicine, The Arctic University of Norway, Tromsø, Norway.
          [4 ] Department of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway Department of Medical Biology, The Arctic University of Norway, Tromsø, Norway.
          Article
          35/2/865
          25667468
          Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

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