Observation on therapeutic effect of Bushen Zhuangyao extractum combined with Bushen Quyu acupuncture on acute onset of lumbar intervertebral disc herniation

Abstract

Objective To study the therapeutic effect of Bushen Zhuangyao extractum combined with Bushen Quyu acupuncture on acute onset of lumbar intervertebral disc herniation.

Methods A total of 120 patients with lumbar disc herniation admitted to Hubei Provincial Hospital of TCM due to acute onset from October 2016 to December 2018 were included in the study, who were divided into the observation group and the control group by random number table method, 60 cases in each group. Among them, the control group was treated with Bushen Quyu acupuncture, and the observation group was treated with Bushen Zhuangyao extractum orally on the basis of the control group. The curative effect was observed after 2 weeks of continuous treatment, and the changes of JOA low back pain score, ODI score, serum inflammatory factors and pain-related mediators before and after treatment were compared.

Results The total effective rate of the observation group after treatment was 88.3%, which was significantly better than that of the control group (75.0%, χ ² =5.604, P < 0.05). There were no statistically significant differences in JOA low back pain score, ODI score, the inflammatory factor levels of IL-1β, IL-6, IL-10, TNF-α and the levels of pain-related mediator PGE2, 5-HT, BK, NPY between the two groups before treatment (all P > 0.05), which were comparable. Compared with before treatment, the above indicators were significantly improved in both groups after treatment (all P < 0.05). Compared with the control group, the above indicators in the observation group were also significantly improved after treatment (all P < 0.05).

Conclusion Bushen Zhuangyao extractum combined with Bushen Quyu acupuncture for the treatment of acute onset of lumbar intervertebral disc herniation has a significant effect, which can significantly improve the clinical symptoms of patients and reduce the level of inflammatory reaction and pain mediators.

Abstract

摘要：目的研究补肾壮腰膏联合补肾祛瘀针法在腰椎间盘突出症急性发作治疗中的临床疗效。 方法研究纳 入2016年10月一2018年12月期间湖北省中医院收治的因急性发作入院治疗的腰椎间盘突出症患者120例, 采 用随机数字表法分为观察组和对照组各60例, 其中, 对照组行补肾祛瘀针法治疗, 观察组在对照组基础上加用补 肾壮腰膏口服, 均连续治疗2周后观察疗效, 比较治疗前后的JOA下腰痛评分、ODI评分及血清中炎性因子和疼 痛相关介质水平的变化。 结果观察组患者治疗后的总有效率为88.3%, 显著优于对照组的75.0%, 比较差异 有统计学意义 (χ ² = 5.604, P < 0.05)。2组患者治疗前的JOA下腰痛评分、ODI评分以及IL-1β、IL々、IL-10、TNF-α炎性因子水平和PGE2、5-HT、BK、NPY疼痛介质水平比较, 差异均无统计学意义 (均 P > 0.05), 具有可比 性; 与治疗前比较, 2组患者治疗后的上述指标结果均有显著改善 (均 P < 0.05);与对照组比较, 观察组患者治疗 后的上述指标结果亦可见显著改善 (均 P < 0.05)。 结论补肾壮腰膏联合补肾祛瘀针法治疗腰椎间盘突出症急 性发作疗效显著, 能够明显改善患者的临床症状, 并降低炎症反应和疼痛介质水平。