Routine blood test results of Tibetan children and adolescents in plateau areas

Abstract

Objective To investigate routine blood test results and secular changes among Tibetan children and adolescents aged from 3 to 19 in the plateau, and to provide the basis for reference range of routine blood test for this population.

Methods A total of 1 568 Tibetan children and adolescents aged from 3 to 19 living in Shigatse, Tibet were selected by cluster random sampling method. Routine blood test results and its secular trends were compared by age and gender.

Results Significantly differences were found in red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), white blood cell (WBC), neutrophil (NEU), neutrophil percentage (NEU%), lymphocyte (LYM), lymphocyte percentage (LYM%), monocyte percentage (MON%), eosinophil percentage (EOS%), basophil percentage (BAS%) and platelet (PLT) among the four age groups of 3–5, 6–12, 13–15, and 16–19 years ( F/H= 60.22, 179.41, 249.45, 115.03, 74.90, 14.33, 33.46, 78.90, 49.20, 97.29, 24.45, 24.28, 42.65, 20.10, P<0.05). Among red blood cell indexes, RBC, HGB, HCT, MCH increased with age in boys ( F= 148.77, 493.04, 623.14, 249.92, P<0.05), but there was no similar trend in girls ( F= 1.37, 0.15, 2.94, 0.11, P>0.05). HCT showed significant sex differences among the four age groups of 3–5 years, 6–12 years, 13–15 years, and 16–19 years [(41.33±2.31)% vs (41.98±2.40)%; (43.28±2.60)% vs (43.75±2.36)%; (46.20±3.11)% vs (44.83±2.67)%; (51.10±4.15)% vs (43.61±4.70)%, t = −2.10, −2.88, 3.50, 10.82, P<0.051. WBC, NEU, NEU%, LYM, LYM%, monocyte (MON), and MON% increased significantly with age in both boys and girls ( P<0.05). From the age of 12 to 13, RBC, HGB and HCT in Tibetan male and female adolescents showed an opposite trend and widened gradually.

Conclusion Red blood cell index shows significantly different trends among Tibetan adolescents and children of different ages and genders. Regional nationality, age, gender, and other factors should be considered when developing the reference value range of blood routine index.

Abstract

【摘要】 目的 探讨3~19岁髙原世居藏族儿童青少年血常规指标水平及其变化趋势, 为建立该人群血常规参考值范围 提供依据。 方法 采取整群随机抽样方法, 以西藏日喀则地区1 568名3~19岁髙原世居藏族儿童青少年为研究对象, 进 行血常规检测, 比较各年龄组、不同性别人群血常规指标水平并分析其随年龄变化趋势。 结果 红细胞计数(RBC)、血红 蛋白质量浓度(HGB)、红细胞压积(HCT)、平均红细胞体积(MCV)、红细胞平均血红蛋白含量(MCH)、白细胞计数 (WBC)、中性粒细胞计数(NEU)、中性粒细胞计数百分比(NEU%)、淋巴细胞数(LYM)、淋巴细胞数百分比(LYM%)、单核 细胞计数比例(MON%)、嗜酸性粒细胞计数比例(EOS%)、嗜碱性粒细胞计数比例(BAS%)、血小板计数(PLT)在 3~5, 6~12, 13~15, 16~19 岁 4 个年龄段间差异均有统计学意义( F/H 值分别为 60.22, 179.41, 249.45, 115.03, 74.90, 14.34, 33.46, 78.90, 49.20, 97.29, 24.45, 24.28, 42.65, 20.10, P 值均 <0.05), 其中 RBC、HGB、HCT、MCH 红细胞指标在藏族男生中随年龄 呈现上升趋势( F 值分别为 148.77, 493.04, 623.14, 249.92, P值均<0.05), 在女生中无显著变化趋势 ( F 值分别为 1.37, 0.15, 2.94, 0.11, P 值均>0.05)。HCT 在 3~5, 6~12, 13~15, 16~19 岁年龄段的男女生间[(41.33±2.31)%, (41.98±2.40)%; (43.28±2.60)%, (43.75±2.36)%; (46.20±3.11)%, (44.83±2.67)%; (51.10±4.15)%, (43.61±4.70)%] 差异均有统计学意 义( t 值分别为 −2.10, −2.88, 3.50, 10.82, P 值均 <0.05)。WBC、NEU、NEU%、LYM、LYM%、单核细胞计数(MON)、MON% 等 指标在男女中随年龄具有相同的变化趋势( P 值均<0.05)。从12~13岁开始, RBC、HGB、HCT在髙原世居藏族男性与女性 青少年中呈现相反的变化趋势并逐渐拉开差距。 结论 红细胞指标在不同年龄、性别的髙原世居藏族儿童青少年中变化 趋势差异显著, 在制定血常规参考值范围时应考虑地域民族、年龄、性别等因素影响。