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      Diagnostic Value of Urinary Fibrin Degradation Products

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          The concentrations of fibrin degradation products (FDP) in the urine were determined by the passive hemagglutination test in 115 patients with biopsy-proven chronic proliferative glomerulonephritis (GN), 93 patients with urinary tract infection (UTI) and 23 patients who received kidney transplants. The active GN values (12.3 µg/ml) are significantly higher than those for latent GN (0.3 µg/ml). Those for acute UTI (9.2 µg/ml) are significantly higher than for chronic UTI (1.3 µg/ml). In contrast to the reports published by others, the numerous ‘false-positive’ and ‘false-negative’ values make diagnosis of the activity questionable. Prognostic value can be expected in GN with the nephrotic syndrome (NS): patients with steroid-sensitive NS excrete no FDP and patients with steroid-resistant NS excrete larger quantities of FDP. We have confirmed that a rise in the urinary FDP level in transplantation is indicative of rejection. However, since 10 of 27 rejections were FDP-negative, the absence of FDP in the urine does not preclude rejection.

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          S. Karger AG
          02 December 2008
          : 25
          : 1
          : 25-29
          Department of Nephrology, Clinic of Internal Medicine (Director: Prof. H. Klinkmann), University Urological Clinic (Director: Prof. T. Erdman), Immunological Research Department (Head: Prof. H. Friemel), Institute of Physiological Chemistry (Director: Prof. D.Mücke) and Central Laboratory (Director: Prof. W. Dummler), Medical Faculty, Wilhelm Pieck University, Rostock
          181748 Nephron 1980;25:25–29
          © 1980 S. Karger AG, Basel

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          Pages: 5
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