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      Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States

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          Abstract

          The hypothalamus is the main regulatory center of many homeostatic processes, such as reproduction, food intake, and sleep-wake behavior. Recent findings show that there is a strongly interdependent side-linked localization of hypothalamic functions between the left and right hemispheres. The goal of the present study was to trace functional asymmetry of the hypothalamus related to the regulation of food intake and reproduction, in male rodents. Subjects were examined through measurements of mitochondrial metabolism ex vivo. Impact of gonadectomy and scheduled feeding was tested on the modulation of hypothalamic metabolic asymmetry. Results show that in male rats, functional lateralization of the hypothalamus can be attributed to the satiety state rather than to reproductive control. Fasting caused left-sided metabolic dominance, while satiety was linked to the right hemisphere; trends and direction in sided dominance gradually followed the changes in satiety state. Our findings revealed satiety state-dependent metabolic differences between the two hypothalamic hemispheres. It is therefore concluded that, at least in male rats, the hypothalamic hemispheres control the satiety state-related functions in an asymmetric manner.

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          Most cited references 47

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            Mitochondria are central for various cellular processes that include ATP production, intracellular Ca(2+) signaling, and generation of reactive oxygen species. Neurons critically depend on mitochondrial function to establish membrane excitability and to execute the complex processes of neurotransmission and plasticity. While much information about mitochondrial properties is available from studies on isolated mitochondria and dissociated cell cultures, less is known about mitochondrial function in intact neurons in brain tissue. However, a detailed description of the interactions between mitochondrial function, energy metabolism, and neuronal activity is crucial for the understanding of the complex physiological behavior of neurons, as well as the pathophysiology of various neurological diseases. The combination of new fluorescence imaging techniques, electrophysiology, and brain slice preparations provides a powerful tool to study mitochondrial function during neuronal activity, with high spatiotemporal resolution. This review summarizes recent findings on mitochondrial Ca(2+) transport, mitochondrial membrane potential (DeltaPsi(m)), and energy metabolism during neuronal activity. We will first discuss interactions of these parameters for experimental stimulation conditions that can be related to the physiological range. We will then describe how mitochondrial and metabolic dysfunction develops during pathological neuronal activity, focusing on temporal lobe epilepsy and its experimental models. The aim is to illustrate that 1) the structure of the mitochondrial compartment is highly dynamic in neurons, 2) there is a fine-tuned coupling between neuronal activity and mitochondrial function, and 3) mitochondria are of central importance for the complex behavior of neurons.
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                Author and article information

                Contributors
                kiss.david@univet.hu
                toth.istvan@univet.hu
                jocsak.gergely@univet.hu
                bartha.tibor@univet.hu
                frenyo.laszlo@univet.hu
                barany.zoltan.balazs@univet.hu
                tamas.horvath@yale.edu
                zsarnovszky.attila@mkk.szie.hu
                Journal
                Reprod Sci
                Reprod Sci
                Reproductive Sciences
                Springer International Publishing (Cham )
                1933-7191
                1933-7205
                6 January 2020
                6 January 2020
                May 2020
                : 27
                : 5
                : 1197-1205
                Affiliations
                [1 ]GRID grid.483037.b, ISNI 0000 0001 2226 5083, Department of Physiology and Biochemistry, , University of Veterinary Medicine, ; Istvan u. 2, Budapest, 1078 Hungary
                [2 ]GRID grid.21113.30, ISNI 0000 0001 2168 5078, Department of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, , Szent Istvan University, ; Pater Karoly u. 1, Godollo, 2100 Hungary
                [3 ]GRID grid.47100.32, ISNI 0000000419368710, Department of Comparative Medicine, , Yale University School of Medicine, ; 310 Cedar Street, New Haven, CT 06520-8016 USA
                Article
                131
                10.1007/s43032-019-00131-3
                7181557
                32046448
                © The Author(s) 2019

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                Funding
                Funded by: University of Veterinary Medicine (ÁTE)
                Categories
                Original Article
                Custom metadata
                © Society for Reproductive Investigation 2020

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