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      Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States

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          The hypothalamus is the main regulatory center of many homeostatic processes, such as reproduction, food intake, and sleep-wake behavior. Recent findings show that there is a strongly interdependent side-linked localization of hypothalamic functions between the left and right hemispheres. The goal of the present study was to trace functional asymmetry of the hypothalamus related to the regulation of food intake and reproduction, in male rodents. Subjects were examined through measurements of mitochondrial metabolism ex vivo. Impact of gonadectomy and scheduled feeding was tested on the modulation of hypothalamic metabolic asymmetry. Results show that in male rats, functional lateralization of the hypothalamus can be attributed to the satiety state rather than to reproductive control. Fasting caused left-sided metabolic dominance, while satiety was linked to the right hemisphere; trends and direction in sided dominance gradually followed the changes in satiety state. Our findings revealed satiety state-dependent metabolic differences between the two hypothalamic hemispheres. It is therefore concluded that, at least in male rats, the hypothalamic hemispheres control the satiety state-related functions in an asymmetric manner.

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          Most cited references 47

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                Author and article information

                Reprod Sci
                Reprod Sci
                Reproductive Sciences
                Springer International Publishing (Cham )
                6 January 2020
                6 January 2020
                May 2020
                : 27
                : 5
                : 1197-1205
                [1 ]GRID grid.483037.b, ISNI 0000 0001 2226 5083, Department of Physiology and Biochemistry, , University of Veterinary Medicine, ; Istvan u. 2, Budapest, 1078 Hungary
                [2 ]GRID grid.21113.30, ISNI 0000 0001 2168 5078, Department of Animal Physiology and Animal Health, Faculty of Agricultural and Environmental Sciences, , Szent Istvan University, ; Pater Karoly u. 1, Godollo, 2100 Hungary
                [3 ]GRID grid.47100.32, ISNI 0000000419368710, Department of Comparative Medicine, , Yale University School of Medicine, ; 310 Cedar Street, New Haven, CT 06520-8016 USA
                © The Author(s) 2019

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                Funded by: University of Veterinary Medicine (ÁTE)
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                © Society for Reproductive Investigation 2020


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