Hyperthermia mediated by dextran-coated La0.7Sr0.3MnO3 nanoparticles: in vivo studies

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Hyperthermia mediated by dextran-coated La _0.7Sr _0.3MnO ₃ nanoparticles: in vivo studies

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Author(s): Reihaneh Haghniaz , Rinku D Umrani , Kishore M Paknikar

Publication date (Electronic): 27 April 2016

Journal: International Journal of Nanomedicine

Publisher: Dove Medical Press

Keywords: lanthanum strontium manganese oxide nanoparticles, melanoma, tumor regression, survival, heat shock proteins, MRI

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Abstract

Purpose

The aim of this study was to evaluate radiofrequency-induced dextran-coated lanthanum strontium manganese oxide nanoparticles-mediated hyperthermia to be used for tumor regression in mice.

Materials and methods

Nanoparticles were injected intra-tumorally in melanoma-bearing C57BL/6J mice and were subjected to radiofrequency treatment.

Results

Hyperthermia treatment significantly inhibited tumor growth (~84%), increased survival (~50%), and reduced tumor proliferation in mice. Histopathological examination demonstrated immense cell death in treated tumors. DNA fragmentation, increased terminal deoxynucleotidyl transferase-dUTP nick end labeling signal, and elevated levels of caspase-3 and caspase-6 suggested apoptotic cell death. Enhanced catalase activity suggested reactive oxygen species-mediated cell death. Enhanced expression of heat shock proteins 70 and 90 in treated tumors suggested the possible development of “antitumor immunity”.

Conclusion

The dextran-coated lanthanum strontium manganese oxide-mediated hyperthermia can be used for the treatment of cancer.

Most cited references 41

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Effects of crystallization and dopant concentration on the emission behavior of TiO2:Eu nanophosphors

Mou Pal, Umapada Pal, Justo Jiménez … (2012)

Uniform, spherical-shaped TiO2:Eu nanoparticles with different doping concentrations have been synthesized through controlled hydrolysis of titanium tetrabutoxide under appropriate pH and temperature in the presence of EuCl3·6H2O. Through air annealing at 500°C for 2 h, the amorphous, as-grown nanoparticles could be converted to a pure anatase phase. The morphology, structural, and optical properties of the annealed nanostructures were studied using X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy [EDS], and UV-Visible diffuse reflectance spectroscopy techniques. Optoelectronic behaviors of the nanostructures were studied using micro-Raman and photoluminescence [PL] spectroscopies at room temperature. EDS results confirmed a systematic increase of Eu content in the as-prepared samples with the increase of nominal europium content in the reaction solution. With the increasing dopant concentration, crystallinity and crystallite size of the titania particles decreased gradually. Incorporation of europium in the titania particles induced a structural deformation and a blueshift of their absorption edge. While the room-temperature PL emission of the as-grown samples is dominated by the 5D0 - 7F j transition of Eu+3 ions, the emission intensity reduced drastically after thermal annealing due to outwards segregation of dopant ions.

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Magnetic fluid hyperthermia: focus on superparamagnetic iron oxide nanoparticles.

Sophie Laurent, Silvio Dutz, Urs Häfeli … (2011)

Due to their unique magnetic properties, excellent biocompatibility as well as multi-purpose biomedical potential (e.g., applications in cancer therapy and general drug delivery), superparamagnetic iron oxide nanoparticles (SPIONs) are attracting increasing attention in both pharmaceutical and industrial communities. The precise control of the physiochemical properties of these magnetic systems is crucial for hyperthermia applications, as the induced heat is highly dependent on these properties. In this review, the limitations and recent advances in the development of superparamagnetic iron oxide nanoparticles for hyperthermia are presented. Copyright © 2011 Elsevier B.V. All rights reserved.

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Changes in neuronal activation patterns in response to androgen deprivation therapy: a pilot study

Monique M Cherrier, Paul Borghesani, Amy L. Shelton … (2010)

Background A common treatment option for men with prostate cancer is androgen deprivation therapy (ADT). However, men undergoing ADT may experience physical side effects, changes in quality of life and sometimes psychiatric and cognitive side effects. Methods In this study, hormone naïve patients without evidence of metastases with a rising PSA were treated with nine months of ADT. Functional magnetic resonance imaging (fMRI) of the brain during three visuospatial tasks was performed at baseline prior to treatment and after nine months of ADT in five subjects. Seven healthy control patients, underwent neuroimaging at the same time intervals. Results ADT patients showed reduced, task-related BOLD-fMRI activation during treatment that was not observed in control subjects. Reduction in activation in right parietal-occipital regions from baseline was observed during recall of the spatial location of objects and mental rotation. Conclusions Findings, while preliminary, suggest that ADT reduces task-related neural activation in brain regions that are involved in mental rotation and accurate recall of spatial information.

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Author and article information

Journal

Journal ID (nlm-ta): Int J Nanomedicine

Journal ID (iso-abbrev): Int J Nanomedicine

Journal ID (publisher-id): International Journal of Nanomedicine

Title: International Journal of Nanomedicine

Publisher: Dove Medical Press

ISSN (Print): 1176-9114

ISSN (Electronic): 1178-2013

Publication date Collection: 2016

Publication date (Electronic): 27 April 2016

Volume: 11

Pages: 1779-1791

Affiliations

Centre for Nanobioscience, Agharkar Research Institute, Pune, India

Author notes

Correspondence: Rinku D Umrani; Kishore M Paknikar, Centre for Nanobioscience, Agharkar Research Institute, GG Agarkar Road, Pune 411004, Maharashtra, India, Tel +91 20 2532 5127; +91 20 2532 5001, Fax +91 20 2565 1542, Email rinkuumrani@ 123456aripune.org ; kpaknikar@ 123456gmail.com

Article

Publisher ID: ijn-11-1779

DOI: 10.2147/IJN.S104617

PMC ID: 4854252

PubMed ID: 27175076

SO-VID: 7a86e666-5611-482e-b313-f8f6385917a8

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