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      Seroprevalence of Chagas disease in schoolchildren from two municipalities of Jequitinhonha Valley, Minas Gerais, Brazil; six years following the onset of epidemiological surveillance Translated title: Soroprevalência da doença de Chagas em escolares de dois municípios do Vale do Jequitinhonha, Minas Gerais, Brasil, seis anos após a implantação da vigilância epidemiológica

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          Six years after the beginning of the epidemiological surveillance of Chagas disease in Berilo and José Gonçalves de Minas, Jequitinhonha Valley, MG, Brazil, a serological inquiry was performed to observe whether the transmission of this endemy was occurring in this area. A randomized sample of 1,412 children seven to 14 years old, was screened. Six asymptomatic children were found to be positive, leading to 0.4% of prevalence. Hemoculture confirmed infection in five out of the six positive cases. Additional epidemiological investigation revealed important antecedents, such as disease reports in relatives and predisposing ecological and housing conditions. Our results demonstrated similar seroprevalence (0.4%) in schoolchildren, ranging from seven to 14 years old, and that were observed six years ago (0.2%) for children 0-9 year-old. Thus, considering the constant presence of Panstrogylus megistus in the peridomicile these findings emphasize the need of continuous improved epidemiological surveillance of Chagas disease in this region.

          Translated abstract

          Seis anos após o início da vigilância epidemiológica para doença de Chagas em Berilo e José Gonçalves de Minas, Vale do Jequitinhonha, MG, Brasil, foi realizado um inquérito sorológico para verificar se a transmissão desta endemia estava ocorrendo naquela área. Uma amostra aleatória de 1.412 crianças, de 7 a 14 anos, foi avaliada. Foram encontradas seis crianças positivas assintomáticas, totalizando uma prevalência de 0,4%. Hemocultura confirmou a infecção em cinco dos seis casos positivos. Uma investigação epidemiológica adicional, revelou importantes antecedentes, tais como: casos da doença em parentes e condições de moradia e ecológicas predisponentes. Nossos resultados demonstram uma soroprevalência similar (0,4%) em escolares de 7 a 14 anos àquela observada há seis anos (0,2%) em crianças de 0-9 anos. Dessa forma, considerando a presença constante de Panstrogylus megistus estes achados reforçam a necessidade de uma vigilância epidemiológica contínua e aperfeiçoada para Doença de Chagas naquela região.

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          Most cited references 31

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          Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas' disease.

          A double-blind, randomized, clinical field trial was designed to test the efficacy and tolerance of a specific drug treatment in children in the indeterminate phase of infection by Trypanosoma cruzi. Children were treated with benznidazole at a dose of 5 mg/kg/day for 60 days or placebo and followed-up for 48 months. The treated children showed a significant decrease in geometric mean titers of antibodies against T. cruzi measured by indirect hemagglutination, indirect immunofluorescence, and ELISA. After a four year follow-up, 62% of the benznidazole-treated children and no placebo-treated child were seronegative for T. cruzi when tested by an ELISA using a T. cruzi flagellar calcium-binding protein (F29). Xenodiagnosis carried out after 48 months of follow-up was positive in 4.7% of the benznidazole-treated children and in 51.2% of the placebo-treated children. These results show the tolerance to and efficacy of benznidazole against T. cruzi in seropositive children six to 12 years of age. We used an early serologic marker of cure after treatment, consisting of a recombinant antigen implemented in a rapid, conventional serologic procedure.
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            Randomised trial of efficacy of benznidazole in treatment of early Trypanosoma cruzi infection

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              Treatment of chronic Chagas' disease with benznidazole: Clinical and serologic evolution of patients with long-term follow-up


                Author and article information

                Revista do Instituto de Medicina Tropical de São Paulo
                Rev. Inst. Med. trop. S. Paulo
                Instituto de Medicina Tropical (São Paulo, SP, Brazil )
                April 2006
                : 48
                : 2
                : 81-86
                Ouro Preto MG orgnameUFOP orgdiv1ICEB orgdiv2Departamento de Ciências Biológicas Brasil
                Belo Horizonte MG orgnameUFMG orgdiv1Faculdade de Medicina orgdiv2Departamento de Clínica Médica Brasil
                Belo Horizonte MG orgnameFIOCRUZ orgdiv1Centro de Pesquisas René Rachou Brasil
                , Belo Horizonte MG orgnameFundação Ezequiel Dias Brasil
                Ouro Preto MG orgnameUFOP orgdiv1Instituto de Ciências Exatas e Biológicas orgdiv2Núcleo de Pesquisas em Ciências Biológicas Brasil
                Rio de Janeiro RJ orgnameFIOCRUZ orgdiv1IOC orgdiv2Departamento de Medicina Tropical Brasil
                MG orgnameUniversidade Federal de Ouro Preto orgdiv1Escola de Farmácia orgdiv2Departamento de Análises Clínicas Brasil
                Ouro Preto MG orgnameUFOP orgdiv1Escola de Farmácia orgdiv2Departamento de Farmácia Brasil
                S0036-46652006000200005 S0036-4665(06)04800205

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

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                Figures: 0, Tables: 0, Equations: 0, References: 35, Pages: 6
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                Chagas disease

                Children, Serology, Chagas disease prevalence


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