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Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical BleedingClinical Perspective
Corey E. Tabit ,
Phetcharat Chen ,
Gene H. Kim ,
Savitri E. Fedson ,
Gabriel Sayer ,
Mitchell J. Coplan ,
Valluvan Jeevanandam ,
Nir Uriel ,
James K. Liao
July 11 2016
June 28 2016
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Abstract
Nonsurgical bleeding is the most common adverse event in patients with continuous-flow
left ventricular assist devices (LVADs) and is caused by arteriovenous malformations.
We hypothesized that deregulation of an angiogenic factor, angiopoietin-2 (Ang-2),
in patients with LVADs leads to increased angiogenesis and higher nonsurgical bleeding.