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      Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis

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          Abstract

          In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B ( 1), and A ( 2), along with three known sesquiterpenes ( 3–5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 November 2017
          : 15
          : 11
          : 855-859
          Affiliations
          1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
          2Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China
          3State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
          Author notes
          *Corresponding author: WANG De-Cai, E-mail: dcwang@ 123456njtech.edu.cn ; GUO Yue-Wei, Tel/Fax: 86-21-50807088, E-mail: ywguo@ 123456simm.ac.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30019-0
          10.1016/S1875-5364(18)30019-0
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: Natural Science Foundation of China
          Award ID: 81520108028
          Award ID: 21672230
          Award ID: 41506187
          Award ID: 816013016
          Funded by: SKLDR/SIMM Project
          Award ID: SIMM1501ZZ-03
          This work was supported by the Natural Science Foundation of China (Nos. 81520108028, 21672230, 41506187, and 816013016) and the SKLDR/SIMM Project (No. SIMM1501ZZ-03).

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