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      Clavuridins A and B, two new trinor-guaiane sesquiterpenes isolated from the Xisha soft coral Clavularia viridis

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          Abstract

          In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B ( 1), and A ( 2), along with three known sesquiterpenes ( 3–5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3–5 were evaluated for their cytotoxic activity.

          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 November 2017
          : 15
          : 11
          : 855-859
          Affiliations
          [1] 1College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
          [2] 2Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222002, China
          [3] 3State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
          Author notes
          *Corresponding author: WANG De-Cai, E-mail: dcwang@ 123456njtech.edu.cn ; GUO Yue-Wei, Tel/Fax: 86-21-50807088, E-mail: ywguo@ 123456simm.ac.cn

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(18)30019-0
          10.1016/S1875-5364(18)30019-0
          7aa190d8-ed62-4ecb-a21c-dc91835cecc8
          Copyright © 2017 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          History
          : 08 April 2017
          Funding
          Funded by: Natural Science Foundation of China
          Award ID: 81520108028
          Award ID: 21672230
          Award ID: 41506187
          Award ID: 816013016
          Funded by: SKLDR/SIMM Project
          Award ID: SIMM1501ZZ-03
          This work was supported by the Natural Science Foundation of China (Nos. 81520108028, 21672230, 41506187, and 816013016) and the SKLDR/SIMM Project (No. SIMM1501ZZ-03).

          Medicine,Pharmaceutical chemistry,Pharmacology & Pharmaceutical medicine,Complementary & Alternative medicine
          Cytotoxic activity,Trinor-guaiane sesquiterpene, Clavularia viridis ,Soft coral

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