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      Leser-Trélat Sign without Internal Malignancy

      case-report
      Author(s): * ,
      Publication date (Electronic):
      Journal: Case Reports in Oncology
      Publisher: S. Karger AG
      Keywords: Leser-Trélat sign, Paraneoplastic syndrome, Seborrheic keratoses

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          Abstract

          Leser-Trélat sign is characterized by the abrupt appearance of multiple seborrheic keratoses in association with underlying malignant disease. A case of Leser-Trélat sign in a 66-year-old healthy woman is presented. Evaluation and follow-up for the development of malignancy over a 2-year period failed to reveal any evidence of malignancy. To date, almost all cases of Leser-Trélat sign have been reported in association with an underlying malignancy. It is less known that Leser-Trélat sign can also occur in healthy individuals in the absence of internal malignancy.

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          Seborrheic keratosis.

          Christian Hafner, Thomas Vogt (2008)
          Seborrheic keratosis is one of the most common skin tumors. Because this tumor is benign, treatment is not mandatory. However, the lesions are often removed especially for cosmetic reasons. Despite its frequency, many aspects of seborrheic keratosis remain elusive. In the last years new molecular genetic insights into seborrheic keratoses have been gained. The current knowledge about seborrheic keratosis with respect to epidemiology, pathogenesis, diagnosis and therapy is summarized.
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            Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trélat, and multiple acrochordons. A possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes.

            W. Inman, E Chow, Christine E. King … (1987)
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              Sign of Leser-Trélat.

              Allison R. Schwartz (1996)
              The sign of Leser-Trélat is rare. It is defined as the sudden eruption of multiple seborrheic keratoses caused by a malignancy. Because both seborrheic keratoses and cancer are common in the elderly, it is not always easy to tell from the literature or in any given patient if this sign is present. In fact, its validity has been questioned. Its association with malignant acanthosis nigricans is one of several of its features that support its legitimacy as a true paraneoplastic disorder.
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                Author and article information

                Journal
                Journal ID (nlm-ta): Case Rep Oncol
                Journal ID (publisher-id): CRO
                Title: Case Reports in Oncology
                Publisher: S. Karger AG (Allschwilerstrasse 10, P.O. Box · Postfach · Case postale, CH–4009, Basel, Switzerland · Schweiz · Suisse, Phone: +41 61 306 11 11, Fax: +41 61 306 12 34, karger@karger.ch )
                ISSN (Electronic): 1662-6575
                Publication date Collection: Jan-Apr 2011
                Publication date (Electronic): 29 March 2011
                Publication date PMC-release: 29 March 2011
                Volume: 4
                Issue: 1
                Pages: 175-177
                Affiliations
                Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France
                Author notes
                *Dr. Gilles Safa, Department of Dermatology, Centre Hospitalier de Saint-Brieuc, 10, rue Marcel Proust, FR–22000 Saint-Brieuc (France), Tel. +33 296 017 468, E-Mail gilles.safa@ 123456ch-stbrieuc.fr
                Article
                Publisher ID: cro0004-0175
                DOI: 10.1159/000327363
                PMC ID: 3081649
                PubMed ID: 21526136
                SO-VID: 7aae340a-d98e-4c06-bb6a-68b3a88a90de
                Copyright © Copyright © 2011 S. Karger AG, Basel
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License ( http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.

                History
                Page count
                Figures: 1, References: 10, Pages: 3
                Categories
                Subject: Published: March 2011

                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: leser-trélat sign,paraneoplastic syndrome,seborrheic keratoses
                Data availability:
                ScienceOpen disciplines: Oncology & Radiotherapy
                Keywords: leser-trélat sign, paraneoplastic syndrome, seborrheic keratoses

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