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      Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

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      Nature genetics
      Springer Science and Business Media LLC

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          Abstract

          We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).

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          Author and article information

          Journal
          Nat Genet
          Nature genetics
          Springer Science and Business Media LLC
          1546-1718
          1061-4036
          Feb 2009
          : 41
          : 2
          Affiliations
          [1 ] CNRS 8090-Institute of Biology, Pasteur Institute, 59000 Lille, France.
          Article
          ng.301
          10.1038/ng.301
          19151714
          7ab1f680-954e-448f-b972-dcafe381f488
          History

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