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The purpose of this study was to evaluate the potential for the oral sustained delivery
of paracetamol of two formulations with in situ gelling properties. Oral administration
of aqueous solutions of either gellan gum (1.0%, w/v) or sodium alginate (1.5%, w/v)
containing calcium ions in complexed form resulted in the formation of gel depots
in rabbit and rat stomachs as a consequence of the release of the calcium ions in
the acidic environment. In vitro studies demonstrated diffusion-controlled release
of paracetamol from the gels over a period of 6h. The bioavailability of paracetamol
from the gels formed in situ in the stomachs of rabbits following oral administration
of the liquid formulations was similar to that of a commercially available suspension
containing an identical dose of paracetamol.