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      Oral sustained delivery of paracetamol from in situ-gelling gellan and sodium alginate formulations

      International Journal of Pharmaceutics
      Elsevier BV

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          Abstract

          The purpose of this study was to evaluate the potential for the oral sustained delivery of paracetamol of two formulations with in situ gelling properties. Oral administration of aqueous solutions of either gellan gum (1.0%, w/v) or sodium alginate (1.5%, w/v) containing calcium ions in complexed form resulted in the formation of gel depots in rabbit and rat stomachs as a consequence of the release of the calcium ions in the acidic environment. In vitro studies demonstrated diffusion-controlled release of paracetamol from the gels over a period of 6h. The bioavailability of paracetamol from the gels formed in situ in the stomachs of rabbits following oral administration of the liquid formulations was similar to that of a commercially available suspension containing an identical dose of paracetamol.

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          Author and article information

          Journal
          International Journal of Pharmaceutics
          International Journal of Pharmaceutics
          Elsevier BV
          03785173
          June 04 2003
          June 04 2003
          : 258
          : 1-2
          : 55-64
          Article
          10.1016/S0378-5173(03)00163-7
          12753753
          7ac15d72-2a60-4bfb-af8c-fa65682e6862
          © 2003

          https://www.elsevier.com/tdm/userlicense/1.0/

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