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      Hormonal Changes during Puberty

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          Abstract

          Longitudinal studies of plasma dehydroepiandrosterone sulfate (DHEA-S) and dehydroepiandrosterone (DHEA) were made in 13 girls aged 7 years and 14 aged 10 years, during 3 years, at 6-month intervals. Similarly, two groups of 12 boys aged 8 years and 11 years were followed. In addition, 3 girls with premature adrenarche and 4 male patients with Addison’s disease were studied. In the normal girls a significant rise of plasma DHEA-S and DHEA occurred from 6 years of bone age (51.4 ± 9.0 ng/ml and 50.5 ± 9.2 ng/100 ml, respectively) to 8 years (119.7 ± 19.1 ng/ml and 94.5 ± 16.5 ng/100 ml). A further significant rise was apparent at 11 years (385.8 ± 60.9 ng/ml) and 329.0 ± 78.4 ng/ 100 ml). In boys, a similar rise of DHEA-S and DHEA was observed between 6 years of bone age (75.8 ± 12 ng/ml and 44.3 ± 7.6 ng/100 ml) and 8 years (157.4 ± 28.9 ng/ml and 76.1 ± 8.9 ng/100 ml). Further significant rises of DHEA-S and DHEA were seen at 13 years of bone age (563.7 ± 123.7 ng/ml and 267.9 ± 50.0 ng/100 ml, respectively). Testosterone in both sexes rose 2–3 years later than DHEA-S and DHEA. In female patients with premature adrenarche, higher plasma levels of DHEA-S and DHEA were found when compared to normal levels at similar chronological and bone ages. Very low plasma concentrations of DHEA-S and DHEA were observed in the patients with Addison’s disease.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1976
          1976
          25 November 2008
          : 7
          : 4-5
          : 288-302
          Affiliations
          Endocrinology Unit, Department of Pediatrics and Genetics, University of Geneva School of Medicine, Geneva
          Article
          178740 Horm Res 1976;7:288–302
          10.1159/000178740
          138656
          7ad9596d-154d-45cc-8d6f-ba9ed6015b8c
          © 1976 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 15
          Categories
          Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Puberty,Adrenal androgens,Testosterone,Dehydroepiandrosterone,Dehydroepiandrosterone sulfate

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