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      Bioactive glass coatings on metallic implants for biomedical applications

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          Abstract

          Metallic implant materials possess adequate mechanical properties such as strength, elastic modulus, and ductility for long term support and stability in vivo. Traditional metallic biomaterials, including stainless steels, cobalt-chromium alloys, and titanium and its alloys, have been the gold standards for load-bearing implant materials in hard tissue applications in the past decades. Biodegradable metals including iron, magnesium, and zinc have also emerged as novel biodegradable implant materials with different in vivo degradation rates. However, they do not possess good bioactivity and other biological functions. Bioactive glasses have been widely used as coating materials on the metallic implants to improve their integration with the host tissue and overall biological performances. The present review provides a detailed overview of the benefits and issues of metal alloys when used as biomedical implants and how they are improved by bioactive glass-based coatings for biomedical applications.

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          Highlights

          • Coating necessity for different metallic implant materials.

          • Comparison of bioactive glass coating methods.

          • Summary of bioactive glass and composite coatings.

          • Bioactive glass coating criteria and evaluation routines.

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          Most cited references117

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          The story of Bioglass.

          Historically the function of biomaterials has been to replace diseased or damaged tissues. First generation biomaterials were selected to be as bio-inert as possible and thereby minimize formation of scar tissue at the interface with host tissues. Bioactive glasses were discovered in 1969 and provided for the first time an alternative; second generation, interfacial bonding of an implant with host tissues. Tissue regeneration and repair using the gene activation properties of Bioglass provide a third generation of biomaterials. This article reviews the 40 year history of the development of bioactive glasses, with emphasis on the first composition, 45S5 Bioglass, that has been in clinical use since 1985. The steps of discovery, characterization, in vivo and in vitro evaluation, clinical studies and product development are summarized along with the technology transfer processes.
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            Biodegradable metals

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              Metallic implant biomaterials

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                Author and article information

                Contributors
                Journal
                Bioact Mater
                Bioact Mater
                Bioactive Materials
                KeAi Publishing
                2452-199X
                05 October 2019
                December 2019
                05 October 2019
                : 4
                : 261-270
                Affiliations
                [a ]Department of Materials Science and Engineering, University of North Texas, Denton, TX, 76203, USA
                [b ]Department of Biomedical Engineering, University of North Texas, Denton, TX, 76203, USA
                [c ]Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA
                Author notes
                []Corresponding author. Donghui.Zhu@ 123456stonybrook.edu
                [∗∗ ]Corresponding author. Jincheng.Du@ 123456unt.edu
                [1]

                These authors contributed equally to this work.

                Article
                S2452-199X(19)30046-5
                10.1016/j.bioactmat.2019.09.002
                6812334
                31667443
                7ae3c64c-2813-4c6c-baac-a327779ed337
                .

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 4 September 2019
                : 25 September 2019
                : 28 September 2019
                Categories
                Article

                bioactive glass coating,metallic biomaterials,biodegradation,biocompatibility,bioactivity. contents

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