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      Evidence Suggesting that the Sympathetic Nervous System Mediates Thyroidal Depression in Turpentine-Induced Nonthyroidal Illness Syndrome

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          Abstract

          Acute superior cervical ganglionectomy (SCGx) induces in the rat a supraliminal release of neurotransmitter in the innervated tissues (i.e., thyroid gland). This temporary adrenergic hyperactivity is correlated with a significant depression of the thyroid economy resembling the nonthyroidal illness (NTT) syndrome in the rat, and suggest that the sympathetic nervous system may mediate thyroidal changes in NTI. In order to gain further insight into the thyroidal depression in the NT! syndrome, we studied the thyroidal norepinephrine (NE) turnover in turpentine oil (TURP)-induced NT syndrome and the role of the cervical ganglia (SCG) in the development of NΗ in the rat. TURP administration to sham operated rats induced a rapid and significant fall in plasma T4 and TSH levels, in the thyroidal response to exogenous TSH (ΗU) and in the thyroidal NE content compared to controls (sham + saline) (T4: 3.1 ± 0.3 vs. 5.1 ± 0.6 µg/dl, respectively, mean ± SE, p < 0.02; TSH: 1.4 ± 0.4 vs. 4.7 ± 1.4 ng/ml, respectively, p < 0.05; ΗU: 92 ± 14vs 201 ± 20 cpm µl thyroid/cpm·mg plasma (T/P ratio), respectively, p < 0.01; thyroidal NE: 680 ± 20 vs. 761 ± 29 pg/mg thyroid, respectively, p < 0.05). The thyroidal turnover rate of NE, however, was significantly increased in TURP-injected rats compared to controls (122 ± 13 vs. 86 ± 10 pg/mg/h, respectively, p < 0.05). TURP injection to chronic SCGx rats induced a similar fall in plasma TSH compared to controls (SCGx + saline) (1.3 ± 0.2 vs. 4.3 ± 1.1 ng/ml, respectively, p < 0.02); plasma T4 and TIU, however, did not change significantly (T4: 3.4 ± 0.4 vs. 3.7 ± 0.3 µg/dl, respectively, NS; ΗU: 172 ± 8 vs. 226 ± 27 T/P ratio, respectively, NS). Denervation of thyroid gland by sectioning of the external carotid nerve (ECNx) also blocked the fall in ΗU induced by TURP; on the other hand, a section of the internal carotid nerve (ICNx) (which does not innervate the thyroid gland) failed to prevent TURP effect on TIU (T/P ratio: sham + saline, 359 ± 58 vs. sham + TURP, 190 ± 23, p < 0.025; ECNx + saline, 266 ± 42 vs. ECNx + TURP, 274 ± 39, NS; ICNx + saline, 290 ± 57 vs. ICNx + TURP, 152 ± 29, p < 0.02). Our data suggest that (1) the NΠ is associated with an increase of the thyroidal NE turnover; (2) the SNS mediates the fall in plasma T4 and inTIU observed in NΠ syndrome through changes in the activity of the SCG, and (3) TSH fall in NΠ appears to be unrelated to SCG activity.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1991
          1991
          04 April 2008
          : 53
          : 4
          : 360-364
          Affiliations
          Laboratorio de Investigaciones Endocrinologicas, Hospital de Clínicas and Catedra de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
          Article
          125742 Neuroendocrinology 1991;53:360–364
          10.1159/000125742
          2046869
          7aea8f64-c5de-495a-97a7-dfc55df74c5e
          © 1991 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 12 June 1990
          : 17 September 1990
          Page count
          Pages: 5
          Categories
          Original Paper

          Endocrinology & Diabetes,Neurology,Nutrition & Dietetics,Sexual medicine,Internal medicine,Pharmacology & Pharmaceutical medicine
          Thyroid,Superior cervical ganglia,Nonthyroidal illness syndrome

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