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      Comparison of Buffering Capacity in Patients on Hemodialysis and Continuous Ambulatory Peritoneal Dialysis

      a , b , c , c


      S. Karger AG

      Acid load, Buffer capacity, CAPD, Hemodialysis

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          A standard acid loading test was used to assess the buffering capacity in 9 hemodialysis (HD) and 25 continuous ambulatory peritoneal dialysis (CAPD) patients. There was a significant increase in H<sup>+</sup> concentration and a decrease in plasma bicarbonate levels after the acid loading in all patients; however, PaCO<sub>2</sub> did not change significantly. CAPD patients tolerated the acid load better, at least in the first 2 h, than HD patients. The brief duration of experiments did not allow us to observe differences, if any, in the recovery rates between HD and CAPD patients. CAPD patients tolerated the acid load equally, whether studied with or without fresh dialysate in the peritoneal cavity. Their tolerance to the acid load did not change with an increasing duration of the CAPD therapy. Baseline values and acid tolerance curves were similar in CAPD patients on regular Dianeal (lactate 35 mEq/l) and Dianeal PD2 (lactate 40 mEq/l). It is concluded that the buffering capacity is marginally higher in CAPD than in HD patients, although the baseline acid-base parameters were essentially identical.

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          Author and article information

          S. Karger AG
          04 December 2008
          : 42
          : 1
          : 29-33
          aDepartment of Medicine, Veterans’Administration Medical Center, University of Cincinnati Medical Center; bDepartment of Medicine, University of Cincinnati Medical Center; cNephrology Section, Veterans’s Administration Medical Center, Cincinnati, Ohio, USA
          183629 Nephron 1986;42:29–33
          © 1986 S. Karger AG, Basel

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          Page count
          Pages: 5
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hemodialysis, CAPD, Buffer capacity, Acid load


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