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Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction.
Mary M Chen
1 ,
Euan A Ashley ,
David X F Deng ,
Anya Tsalenko ,
Alicia Deng ,
Raymond Tabibiazar ,
Amir Ben-Dor ,
Brett Fenster ,
Eugene Yang ,
Jennifer Y King ,
Michael Fowler ,
Robert Robbins ,
Frances L Johnson ,
Laurakay Bruhn ,
Theresa McDonagh ,
Henry Dargie ,
Zohar Yakhini ,
Philip S Tsao ,
Thomas Quertermous
Sep 23 2003
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Abstract
Apelin is among the most potent stimulators of cardiac contractility known. However, no physiological or pathological role for apelin-angiotensin receptor-like 1 (APJ) signaling has ever been described.