<p class="first" id="P1">Nanoparticles are widely used as contrast and therapeutic
agents. As such, imaging
modalities that can accurately estimate their distribution in-vivo are actively sought.
We present here our method Magneto Acoustic Tomography (MAT), which uses magnetomotive
force due to a short pulsed magnetic field to induce ultrasound in the magnetic nanoparticle
labeled tissue and estimates an image of the distribution of the nanoparticles in-vivo
with ultrasound imaging resolution. In this study, we image the distribution of superparamagnetic
iron oxide nanoparticles (IONP) using MAT method. In-vivo imaging was performed on
live, nude mice with IONP injected into lymph node derived cancer of the prostate
tumors induced over the hind limb of the mice. Our experimental results indicate that
the MAT method is capable of imaging the distribution of IONPs in-vivo. Therefore,
MAT could become an imaging modality for high resolution reconstruction of MNP distribution
in the body.
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</p><p id="P3">In magneto acoustic tomography a short pulsed magnetic field is applied
ultrasound in tissue labeled with magnetic nanoparticle through magneto motive force.
Using ultrasound transducers placed around the object this ultrasound wave is measured.
The reconstructed image from the ultrasound signal is a representation of the distribution
of the magnetic nanoparticles in the tissue. This is shown in the present study with
in-vivo experiments to detect and image the distribution of IONPs in live, nude mice
with induced lymph node derived cancer of the prostate tumors over the hind limb.