Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

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Abstract

Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.

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Most cited references 154

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Liposomes as nanomedical devices

Giuseppina Bozzuto, Agnese Molinari (2015)

Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the “first-generation” liposomes, and liposome-based drugs on the market and in clinical trials.

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Curcumin: the story so far.

R A Sharma, A Gescher, W Steward (2005)

Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse anti-inflammatory and anti-cancer properties following oral or topical administration. Apart from curcumin's potent antioxidant capacity at neutral and acidic pH, its mechanisms of action include inhibition of several cell signalling pathways at multiple levels, effects on cellular enzymes such as cyclooxygenase and glutathione S-transferases, immuno-modulation and effects on angiogenesis and cell-cell adhesion. Curcumin's ability to affect gene transcription and to induce apoptosis in preclinical models is likely to be of particular relevance to cancer chemoprevention and chemotherapy in patients. Although curcumin's low systemic bioavailability following oral dosing may limit access of sufficient concentrations for pharmacological effect in certain tissues, the attainment of biologically active levels in the gastrointestinal tract has been demonstrated in animals and humans. Sufficient data currently exist to advocate phase II clinical evaluation of oral curcumin in patients with invasive malignancy or pre-invasive lesions of the gastrointestinal tract, particularly the colon and rectum.

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Counting on natural products for drug design.

Tiago Rodrigues, Daniel Reker, Petra Schneider … (2016)

Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery.

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Journal

Journal ID (nlm-ta): J Clin Med

Journal ID (iso-abbrev): J Clin Med

Journal ID (publisher-id): jcm

Title: Journal of Clinical Medicine

Publisher: MDPI

ISSN (Electronic): 2077-0383

Publication date (Electronic): 10 March 2020

Publication date Collection: March 2020

Volume: 9

Issue: 3

Electronic Location Identifier: 746

Affiliations

[1 ]Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran; bahar.salehi007@ 123456gmail.com

[2 ]Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito Exterior S/N, Del. Coyoacán, Mexico City 04510, Mexico; luisa.delpradoa@ 123456gmail.com (M.L.D.P.-A.); gerardoleyva@ 123456hotmail.com (G.L.-G.)

[3 ]Laboratorio de Posgrado en Tecnología Farmacéutica, FES-Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli 54740, Mexico

[4 ]Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City 14389, Mexico; hcortes_c@ 123456hotmail.com

[5 ]Department of Biology and Ecology, Faculty of Science and Mathematics, University of Niš, 18000 Niš, Serbia; zstojanovicradic@ 123456yahoo.com

[6 ]Department of Post-Harvest Technology, College of Horticulture and Forestry, Central Agricultural University, Pasighat 791102, Arunachal Pradesh, India; disco.iitg@ 123456gmail.com

[7 ]Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyangsi 10326, Korea; jkpatra.cet@ 123456gmail.com (J.K.P.); gitishreedas@ 123456gmail.com (G.D.)

[8 ]Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal

[9 ]Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal

[10 ]Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile

[11 ]Unidad de Desarrollo Tecnológico, Universidad de Concepción UDT, Concepcion 4070386, Chile

[12 ]Research Department of Agronomy and Plant Breeding, Agricultural Research Institute, University of Zabol, Zabol 3585698613, Iran; marzieh.sharifirad@ 123456gmail.com

[13 ]Department of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, China

[14 ]Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1991953381, Iran

Author notes

[* ]Correspondence: ncmartins@ 123456med.up.pt (N.M.); mmartorell@ 123456udec.cl (M.M.); chocs@ 123456ha.org.hk (W.C.C.); javad.sharifirad@ 123456gmail.com (J.S.-R.)

Author information

Bahare Salehi https://orcid.org/0000-0002-6900-9797

María L. Del Prado-Audelo https://orcid.org/0000-0003-4238-2724

Hernán Cortés https://orcid.org/0000-0002-6147-4109

Gerardo Leyva-Gómez https://orcid.org/0000-0002-7940-1100

Yengkhom Disco Singh https://orcid.org/0000-0002-7580-2345

Jayanta Kumar Patra https://orcid.org/0000-0003-4118-4355

Natália Martins https://orcid.org/0000-0002-5934-5201

Miquel Martorell https://orcid.org/0000-0003-3183-7623

William C. Cho https://orcid.org/0000-0003-4174-4586

Javad Sharifi-Rad https://orcid.org/0000-0002-7301-8151

Article

Publisher ID: jcm-09-00746

DOI: 10.3390/jcm9030746

PMC ID: 7141226

PubMed ID: 32164244

SO-VID: 7b2dfd26-cf86-45f2-9248-baf229b21495

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Therapeutic Applications of Curcumin Nanomedicine Formulations in Cardiovascular Diseases

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Wits Journal of Clinical Medicine

Most cited references 154

Liposomes as nanomedical devices

Curcumin: the story so far.

Counting on natural products for drug design.

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