0
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Growth Response to Growth-Hormone Administration during the Decelerating Phase of the Pubertal Growth Spurt in Short Normal Children

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          In order to investigate the value of growth hormone (GH) treatment during late puberty, we studied the effect of human GH (hGH) administration (0.85 ± 0.30 IU/kg/week; range: 0.44–1.28) on height velocity (HV) after the peak of the pubertal growth spurt in a group of 10 (4 girls and 6 boys) short normal children (GH peak after pharmacological stimulation: 15.5 ± 2.3 ng/ml) with growth retardation (height: 2.6 ± 0.3 SD) and puberty Tanner stage 4. A group of 10 untreated children, observed prior to the study, served as controls. The children were regularly measured during their pubertal growth spurt, and HV (cm/year) was calculated every 6 months. The pretreatment evaluation consisted of 2 consecutive 6-month periods characterized by a decrease in HV of at least 25%. In the group of selected children, hGH administration was then initiated and growth variables were evaluated after 6 and 12 months of therapy. Skeletal maturation was evaluated at the beginning as well as after 6 months and 12 months of hGH therapy. In the controls, HV (mean ± SD) had decreased from 8.8 ± 1.8 to 4.9 ± 1.4 cm/year during the pretreatment period (in girls from 7.9 ± 1.4 to 4.1 ± 0.6 cm/year and in boys from 9.6 ± 1.6 to 5.8 ± 1.2 cm/year). During the following semester, HV was 3.3 ± 0.8 cm/year (girls: 3.4 ± 1.0 and boys: 3.2 ± 0.2 cm/year). In the group of children treated with hGH, HV had decreased from 8.3 ± 1.3 to 5.3 ± 0.8 cm/year (from 7.5 ± 0.8 to 5.0 ± 0.2 cm/year in girls and from 8.9 ± 1.0 to 5.5 ± 0.8 cm/year in boys). During the first 6 months of hGH, HV was 7.7 ± 2.0 cm/year (7.5 ± 1.6 cm/year in girls and 7.8 ± 2.0 cm/year in boys). During the second 6-month period of treatment, a waning effect of GH was observed since HV decreased to 4.5 ± 1.4 cm/year (4.3 ± 1.4 cm/year in girls and 4.6 ± 1.5 cm/year in boys). We conclude that in this group of short normal children hGH (mean dose of 0.85 ± 0.30 IU/kg/week) increased HV after the peak of the pubertal growth spurt; complementary trials are indicated to determine if final adult height is enhanced when this therapy is administered during late puberty.

          Related collections

          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1990
          1990
          02 December 2008
          : 34
          : 5-6
          : 204-208
          Affiliations
          aCentre d’Explorations Endocriniennes Pédiatriques, Bordeaux, bSanofi-Recherche, Paris, France
          Article
          181826 Horm Res 1990;34:204–208
          10.1159/000181826
          2100276
          © 1990 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Original Paper

          Comments

          Comment on this article