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      Pulsatile Nature of Luteinizing Hormone Release Is Maintained during Luteinizing Hormone-Releasing Hormone Stimulation in Normal Male Rats

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          Abstract

          The plasma LH concentration is believed to be reasonably steady in normal male rats. We found that LH is released in a regular pulsatile fashion. The overall mean concentration of plasma LH in normal male rats was 46.6 ± 4.4 (mean ± SEM) ng/ml. The normal male rats showed periodic LH pulses: the mean pulse amplitude was 144.4 ± 25.5 ng/ml and the inter-peak interval was 22.5 ± 2.0 min. Each pulse lasted 9.7 ± 0.8 min. When LH-RH (1 µg/kg) was injected as a bolus, the peak concentration was attained in 10-30 min reaching a peak concentration of 279.4 ± 39.6 ng/ml. Distinct pulsatile bursts of plasma LH were discernible during the period of elevated plasma LH concentration. When a higher dose of LH-RH (5 µg/kg) was administered, the LH concentration slowly increased to a peak concentration of 400.2 ± 38.7 ng/ml in 20-40 min. The pulsatile nature of the LH concentration was recognizable with distinct bursts. We have observed that: (a) normal male rats release LH in a pulsatile fashion with an approximate 20-min inter-peak interval; (b) mean LH pulses last less than 10 min, and (c) the LH pulses are visible even with elevated LH and LH-RH concentrations in the general circulation.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1988
          1988
          28 November 2008
          : 29
          : 5-6
          : 223-228
          Affiliations
          Department of Physiology, Queen’s University, Kingston, Ont., Canada
          Article
          181008 Horm Res 1988;29:223–228
          10.1159/000181008
          3065207
          © 1988 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Original Paper

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