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      [Effects of (-)-epigallocatechin-3-gallate on interleukin-1beta expression in mouse wound healing].

      Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology / Zhongguo xi bao sheng wu xue xue hui zhu ban

      Animals, Catechin, analogs & derivatives, pharmacology, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation, drug effects, Interleukin-1beta, genetics, metabolism, Male, Mice, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Wound Healing

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          Abstract

          (-)-Epigallocatechin-3-gallate (EGCG), a main constituent of green tea polyphenols, plays important roles in antioxidative, anti-senescence, anti-tumor, anti-inflammation and bacterail action. In this study, effects of EGCG on the expression of IL-1beta gene and the IL-1beta level at wound sites during cutaneous wound healing were investigated with histological stain, ELISA and RT-PCR technique. The results show that EGCG (50 mg/L) inhibited the expression of IL-1beta gene and reduced the IL-beta level at wound sites at 72 h after cutaneous wound, but not change the expression of IL-1beta gene and the IL-1beta level at early stage (< or =24 h).

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          19697699

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