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      Comparison of Hemodynamic Responses to Exercise in Hypertensive Patients and in Healthy Subjects Given Angiotensin

      Cardiology

      S. Karger AG

      Hypertension, Angiotensin, Arterial pressure, Exercise, Hemodynamics

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          Abstract

          Eleven healthy subjects received an intravenous infusion of angiotensin that raised their mean arterial blood pressure to the level observed in 15 patients with untreated essential hypertension. A hemodynamic study was carried out in both groups at rest and during a standardized exercise load in the sitting position. The hypertensive patients responded to exercise with significantly steeper increases of both the systolic, mean and diastolic arterial blood pressures than the angiotensin-treated subjects. There were no significant differences between the two groups in terms of heart rate, cardiac output and systemic vascular resistance, but the actual level of the systemic vascular resistance during exercise was significantly higher in the hypertensive patients. These results suggest that increased angiotensin blood levels are not responsible for the exaggerated blood pressure increase on exercise in patients with arterial hypertension.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 4
          : 203-208
          Affiliations
          Department of Medicine I, Sahlgrenska University Hospital, Göteborg
          Article
          169635 Cardiology 1973;58:203–208
          10.1159/000169635
          4361632
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 6
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