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      Gene expression of MAGE-A3 and PRAME tumor antigens and EGFR mutational status in Taiwanese non-small cell lung cancer patients.

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          Abstract

          To determine the frequency of expression of the tumor-associated antigens (TAAs) melanoma-associated antigen A3 (MAGE-A3) and preferentially expressed antigen of melanoma (PRAME) and the rate of EGFR mutations in a Taiwanese non-small cell lung cancer (NSCLC) population including only adenocarcinomas and squamous cell carcinomas. Furthermore, to investigate associations between TAA expression and EGFR mutations and to evaluate these TAAs as prognostic markers for overall survival. The occurrence of single nucleotide polymorphisms in MAGEA3 and PRAME was also assessed.

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          Author and article information

          Journal
          Asia Pac J Clin Oncol
          Asia-Pacific journal of clinical oncology
          Wiley
          1743-7563
          1743-7555
          Oct 2017
          : 13
          : 5
          Affiliations
          [1 ] Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.
          [2 ] Genome and Systems Biology Program, National Taiwan University and Academia Sinica, Taipei, Taiwan.
          [3 ] Ph.D. Program in Translational Medicine, National Taiwan University and Academia Sinica, Taipei, Taiwan.
          [4 ] Center for Genomic Medicine, National Taiwan University, Taipei, Taiwan.
          [5 ] Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan.
          [6 ] Department of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
          [7 ] GSK Vaccines, Rixensart, Belgium.
          [8 ] Institute of Biomedical Sciences, National Chung Hsing University, Taichung, Taiwan.
          [9 ] Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
          [10 ] Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
          [11 ] Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.
          [12 ] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
          Article
          10.1111/ajco.12586
          27519286
          7b6e628b-a39a-46ac-ac87-697dab603d34
          History

          EGFR mutation,non-small cell lung cancer,squamous cell carcinoma,adenocarcinoma,PRAME antigen,MAGE-A3 antigen

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