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      Deep learning based image reconstruction algorithm for limited-angle translational computed tomography

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          Abstract

          As a low-end computed tomography (CT) system, translational CT (TCT) is in urgent demand in developing countries. Under some circumstances, in order to reduce the scan time, decrease the X-ray radiation or scan long objects, furthermore, to avoid the inconsistency of the detector for the large angle scanning, we use the limited-angle TCT scanning mode to scan an object within a limited angular range. However, this scanning mode introduces some additional noise and limited-angle artifacts that seriously degrade the imaging quality and affect the diagnosis accuracy. To reconstruct a high-quality image for the limited-angle TCT scanning mode, we develop a limited-angle TCT image reconstruction algorithm based on a U-net convolutional neural network (CNN). First, we use the SART method to the limited-angle TCT projection data, then we import the image reconstructed by SART method to a well-trained CNN which can suppress the artifacts and preserve the structures to obtain a better reconstructed image. Some simulation experiments are implemented to demonstrate the performance of the developed algorithm for the limited-angle TCT scanning mode. Compared with some state-of-the-art methods, the developed algorithm can effectively suppress the noise and the limited-angle artifacts while preserving the image structures.

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          The Cancer Imaging Archive (TCIA): maintaining and operating a public information repository.

          The National Institutes of Health have placed significant emphasis on sharing of research data to support secondary research. Investigators have been encouraged to publish their clinical and imaging data as part of fulfilling their grant obligations. Realizing it was not sufficient to merely ask investigators to publish their collection of imaging and clinical data, the National Cancer Institute (NCI) created the open source National Biomedical Image Archive software package as a mechanism for centralized hosting of cancer related imaging. NCI has contracted with Washington University in Saint Louis to create The Cancer Imaging Archive (TCIA)-an open-source, open-access information resource to support research, development, and educational initiatives utilizing advanced medical imaging of cancer. In its first year of operation, TCIA accumulated 23 collections (3.3 million images). Operating and maintaining a high-availability image archive is a complex challenge involving varied archive-specific resources and driven by the needs of both image submitters and image consumers. Quality archives of any type (traditional library, PubMed, refereed journals) require management and customer service. This paper describes the management tasks and user support model for TCIA.
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            Deep Convolutional Neural Network for Inverse Problems in Imaging.

            In this paper, we propose a novel deep convolutional neural network (CNN)-based algorithm for solving ill-posed inverse problems. Regularized iterative algorithms have emerged as the standard approach to ill-posed inverse problems in the past few decades. These methods produce excellent results, but can be challenging to deploy in practice due to factors including the high computational cost of the forward and adjoint operators and the difficulty of hyper parameter selection. The starting point of our work is the observation that unrolled iterative methods have the form of a CNN (filtering followed by point-wise nonlinearity) when the normal operator ( H*H where H* is the adjoint of the forward imaging operator, H ) of the forward model is a convolution. Based on this observation, we propose using direct inversion followed by a CNN to solve normal-convolutional inverse problems. The direct inversion encapsulates the physical model of the system, but leads to artifacts when the problem is ill-posed; the CNN combines multiresolution decomposition and residual learning in order to learn to remove these artifacts while preserving image structure. We demonstrate the performance of the proposed network in sparse-view reconstruction (down to 50 views) on parallel beam X-ray computed tomography in synthetic phantoms as well as in real experimental sinograms. The proposed network outperforms total variation-regularized iterative reconstruction for the more realistic phantoms and requires less than a second to reconstruct a 512 x 512 image on the GPU.
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              Algebraic reconstruction techniques (ART) for three-dimensional electron microscopy and x-ray photography.

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole: Project administrationRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: InvestigationRole: Visualization
                Role: Data curationRole: Software
                Role: SoftwareRole: SupervisionRole: Writing – review & editing
                Role: Funding acquisitionRole: InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                6 January 2020
                2020
                : 15
                : 1
                : e0226963
                Affiliations
                [1 ] Key Laboratory of Optoelectronic Technology and System of the Education Ministry of China, Chongqing University, Chongqing, China
                [2 ] Engineering Research Center of Industrial Computed Tomography Nondestructive Testing of the Education Ministry of China, Chongqing University, Chongqing, China
                [3 ] College of Computer Science, Civil Aviation Flight University of China, Guanghan Sichuan, China
                [4 ] College of Mathematics and Statistics, Chongqing University, Chongqing, China
                [5 ] College of Mathematics and Statistics, Chongqing Technology and Business University, Chongqing, China
                Zhejiang University, CHINA
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                http://orcid.org/0000-0003-4130-0483
                Article
                PONE-D-19-11599
                10.1371/journal.pone.0226963
                6944462
                31905225
                7b9bde8d-8bc7-4e89-86fa-dcfa419824ef
                © 2020 Wang et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 23 April 2019
                : 9 December 2019
                Page count
                Figures: 14, Tables: 6, Pages: 20
                Funding
                Funded by: National Natural Science Foundation of China
                Award ID: 61771003
                Award Recipient :
                Funded by: National Natural Science Foundation of China
                Award ID: 61701174
                Funded by: National Instrumentation Program of China
                Award ID: 2013YQ030629
                This work was supported in part by the National Natural Science Foundation of China under Grant 61771003 and 61701174, in part by National Instrumentation Program of China under Grant 2013YQ030629.
                Categories
                Research Article
                Research and Analysis Methods
                Imaging Techniques
                Physical Sciences
                Mathematics
                Applied Mathematics
                Algorithms
                Research and Analysis Methods
                Simulation and Modeling
                Algorithms
                Research and Analysis Methods
                Imaging Techniques
                Neuroimaging
                Computed Axial Tomography
                Biology and Life Sciences
                Neuroscience
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                Engineering and Technology
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                Image Processing
                Computer and Information Sciences
                Artificial Intelligence
                Machine Learning
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                Custom metadata
                The TCIA data underlying this study are third party data that are available from DOI: 10.1007/s10278-013-9622-7. The authors do not have special access privileges to these data and confirm that interested researchers may access them via the link provided.

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