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      Growth Hormone and Fertility Clinical Studies

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          Abstract

          The linkage between the reproductive and somatotropic axes and the existence of a complex regulating system within the ovary involving growth factors and their binding proteins suggest that the ovary may be a target of growth hormone (GH) action. Clinical studies investigating possible applications of adjuvant GH treatment in ovulation induction and in vitro fertilization, mainly directed at poor responders to gonadotropin therapy, have shown that results are dependent on the hormonal status and ‘Ovarian age’ of the subject. Additive GH is capable of increasing the sensitivity of ovaries to gonadotropins in those with a blatant or subtile lack of GH but not in those with a normal, saturated system. Improved pregnancy rates have not been convincingly forthcoming and more research is needed on the effect of GH and growth factors on the oocyte and endometrium. Disturbed GH kinetics in the polycystic ovary syndrome have prompted investigations of possible involvement of GH in the pathophysiology of this syndrome.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6280-5
          978-3-318-00020-7
          1663-2818
          1663-2826
          1996
          1996
          09 December 2008
          : 45
          : 1-2
          : 81-85
          Affiliations
          Fertility Unit, Golda Medical Center, Petah Tikva, Israel
          Article
          184764 Horm Res 1996;45:81–85
          10.1159/000184764
          8742124
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 5
          Categories
          Session 3: GH and Gonadal Hormones

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