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      Giant aneurysms of the sinuses of Valsalva and aortic regurgitation in a patient with Noonan's syndrome.

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          Abstract

          Noonan's syndrome is one of the commonest hereditary syndromes with cardiac involvement. We report a rare presentation of this syndrome, associated with giant aneurysms of the left and non-coronary sinuses of Valsalva, resulting in symptomatic aortic valve regurgitation. The patient's clinical investigations and operative management are presented. Histological examination of aortic tissues offers insight into the pathogenesis of these complications.

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          Author and article information

          Journal
          Eur J Cardiothorac Surg
          European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
          Elsevier BV
          1010-7940
          1010-7940
          Aug 2005
          : 28
          : 2
          Affiliations
          [1 ] Department of Cardiology, University Hospital of Wales, Heath Park, Cardiff, UK. richardpurnell@aol.com
          Article
          S1010-7940(05)00392-1
          10.1016/j.ejcts.2005.05.004
          15964762

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