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      Candida Endocarditis in Patients with Candidemia: A Single-Center Experience of 14 Cases

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          Abstract

          A retrospective, single-center analysis of 14 cases of Candida endocarditis (from 355 candidemia cases during the years 2012–2019) revealed a high in-hospital mortality (57.1%), a high proportion of healthcare-associated infections (13/14) and a high treatment preference for echinocandins. Transthoracic echocardiography and 18F-FDG PET/CT had a sensitivity of 54.5% and 57.1%, respectively. Patients were older than previously described and most patients with Candida endocarditis had persistent candidemia for ≥ 3 days despite antifungal therapy.

          Electronic supplementary material

          The online version of this article (10.1007/s11046-020-00492-3) contains supplementary material, which is available to authorized users.

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          Most cited references12

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          2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM).

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            Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.

            It is important to realize that guidelines cannot always account for individual variation among patients. They are not intended to supplant physician judgment with respect to particular patients or special clinical situations. IDSA considers adherence to these guidelines to be voluntary, with the ultimate determination regarding their application to be made by the physician in the light of each patient's individual circumstances.
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              Candida Infective Endocarditis: an Observational Cohort Study with a Focus on Therapy

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                Author and article information

                Contributors
                florian.hitzenbichler@ukr.de
                Journal
                Mycopathologia
                Mycopathologia
                Mycopathologia
                Springer Netherlands (Dordrecht )
                0301-486X
                1573-0832
                9 October 2020
                9 October 2020
                2020
                : 185
                : 6
                : 1057-1067
                Affiliations
                [1 ]GRID grid.411941.8, ISNI 0000 0000 9194 7179, Department of Infection Prevention and Infectious Diseases, , University Hospital Regensburg, ; Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
                [2 ]GRID grid.411941.8, ISNI 0000 0000 9194 7179, Institute of Clinical Microbiology and Hygiene, , University Hospital Regensburg, ; Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
                [3 ]GRID grid.411941.8, ISNI 0000 0000 9194 7179, Department of Nuclear Medicine, , University Hospital Regensburg, ; Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
                [4 ]GRID grid.411941.8, ISNI 0000 0000 9194 7179, Department of Cardiothoracic Surgery, , University Hospital Regensburg, ; Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
                [5 ]GRID grid.411941.8, ISNI 0000 0000 9194 7179, Department of Internal Medicine II, , University Hospital Regensburg, ; Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany
                Author notes

                Handling Editor: Vishnu Chaturvedi.

                Author information
                http://orcid.org/0000-0003-4374-2787
                Article
                492
                10.1007/s11046-020-00492-3
                7779412
                33034836
                7bec026c-5003-4055-b0f0-a34cd8493134
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 16 December 2019
                : 18 September 2020
                Funding
                Funded by: Universitätsklinikum Regensburg (8921)
                Categories
                Short Communication
                Custom metadata
                © Springer Nature B.V. 2020

                Infectious disease & Microbiology
                candida,candidemia,endocarditis,18f-fdg pet/ct,echinocandins,outcome
                Infectious disease & Microbiology
                candida, candidemia, endocarditis, 18f-fdg pet/ct, echinocandins, outcome

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