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      Neuroprotective and antidepressant-like effects of melatonin in a rotenone-induced Parkinson's disease model in rats.

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          Abstract

          Parkinson׳s disease (PD) is a neurodegenerative disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Systemic and intranigral exposure to rotenone in rodents reproduces many of the pathological and behavioral features of PD in humans and thus has been used as an animal model of the disease. Melatonin is a neurohormone secreted by the pineal gland, which has several important physiological functions. It has been reported to be neuroprotective in some animal models of PD. The present study investigated the effects of prolonged melatonin treatment in rats previously exposed to rotenone. The animals were intraperitoneally treated for 10 days with rotenone (2.5mg/kg) or its vehicle. 24h later, they were intraperitoneally treated with melatonin (10mg/kg) or its vehicle for 28 days. One day after the last rotenone exposure, the animals exhibited hypolocomotion in the open field test, which spontaneously reversed at the last motor evaluation. We verified that prolonged melatonin treatment after dopaminergic lesion did not alter motor function but produced antidepressant-like effects in the forced swim test, prevented the rotenone-induced reduction of striatal dopamine, and partially prevented tyrosine hydroxylase immunoreactivity loss in the SNpc. Our results indicate that melatonin exerts neuroprotective and antidepressant-like effects in the rotenone model of PD.

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          Author and article information

          Journal
          Brain Res.
          Brain research
          Elsevier BV
          1872-6240
          0006-8993
          Dec 17 2014
          : 1593
          Affiliations
          [1 ] Pharmacology Department, Federal University of Paraná, Brazil.
          [2 ] Physiology Department, Federal University of Paraná, Brazil.
          [3 ] Pharmacology Department, Federal University of Paraná, Brazil. Electronic address: vital@ufpr.br.
          Article
          S0006-8993(14)01341-9
          10.1016/j.brainres.2014.09.068
          25301688
          7bf3157d-952e-4105-a7f7-130fce3f2eba
          History

          Antidepressant,Melatonin,Neuroprotective,Parkinson׳s disease,Rotenone

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