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      Breast cancer: origins and evolution.

      1
      The Journal of clinical investigation
      American Society for Clinical Investigation

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          Abstract

          Breast cancer is not a single disease, but rather is composed of distinct subtypes associated with different clinical outcomes. Understanding this heterogeneity is key for the development of targeted cancer-preventative and -therapeutic interventions. Current models explaining inter- and intratumoral diversity are the cancer stem cell and the clonal evolution hypotheses. Although tumor initiation and progression are predominantly driven by acquired genetic alterations, recent data implicate a role for microenvironmental and epigenetic changes as well. Comprehensive unbiased studies of tumors and patient populations have significantly advanced our molecular understanding of breast cancer, but translating these findings into clinical practice remains a challenge.

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          Author and article information

          Journal
          J Clin Invest
          The Journal of clinical investigation
          American Society for Clinical Investigation
          0021-9738
          0021-9738
          Nov 2007
          : 117
          : 11
          Affiliations
          [1 ] Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA. kornelia_polyak@dfci.harvard.edu
          Article
          10.1172/JCI33295
          2045618
          17975657
          7bf35315-f3f8-4b1f-a991-e4247ee607cd
          History

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