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      The role of complement factor C3 in lipid metabolism.

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          Abstract

          Abundant reports have shown that there is a strong relationship between C3 and C3a-desArg levels, adipose tissue, and risk factors for cardiovascular disease, metabolic syndrome and diabetes. The data indicate that complement components, particularly C3, are involved in lipid metabolism. The C3 fragment, C3a-desArg, functions as a hormone that has insulin-like effects and facilitates triglyceride metabolism. Adipose tissue produces and regulates the levels of complement components, which promotes generation of inflammatory initiators such as the anaphylatoxins C3a and C5a. The anaphylatoxins trigger a cyto/chemokine response in proportion to the amount of adipose tissue present, and induce inflammation and mediate metabolic effects such as insulin resistance. These observations support the concept that complement is an important participant in lipid metabolism and in obesity, contributing to the metabolic syndrome and to the low-grade inflammation associated with obesity.

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          Author and article information

          Journal
          Mol. Immunol.
          Molecular immunology
          Elsevier BV
          1872-9142
          0161-5890
          Sep 2015
          : 67
          : 1
          Affiliations
          [1 ] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Electronic address: andreea.barbu@igp.uu.se.
          [2 ] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
          [3 ] Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
          Article
          S0161-5890(15)00076-0
          10.1016/j.molimm.2015.02.027
          25746915
          7c031cc1-f9af-48c4-b9bf-309dd74995fc
          History

          Apolipoproteins,C3,C3a-desArg,Metabolic syndrome (MetS),Obesity

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