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      The Ethics of Machine Learning in Medical Sciences: Where Do We Stand Today?

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          Abstract

          Advances in Machine Learning and availability of state-of-the-art computational resources, along with digitized healthcare data, have set the stage for extensive application of artificial intelligence in the realm of diagnosis, prognosis, clinical decision support, personalized treatment options, drug development, and the field of biomedicine. Here, we discuss the application of Machine Learning algorithms in patient healthcare and dermatological domains along with the ethical complexities that are involved. In scientific studies, ethical challenges were initially not addressed proportionally (as assessed by keyword counts in PubMed) and just more recently (since 2016) this has started to improve. Few pioneering countries have created regulatory guidelines around how to respect matters of (1) privacy, (2) fairness, (3) accountability, (4) transparency and (5) conflict of interest when developing novel medical Machine Learning applications. While there is a strong promise of emerging medical applications to ultimately benefit both the patients and the medical practitioners, it is important to raise awareness on the five key ethical issues and incorporate them into medical practice in the near future.

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          Most cited references20

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          Dermatologist-level classification of skin cancer with deep neural networks

          Skin cancer, the most common human malignancy, is primarily diagnosed visually, beginning with an initial clinical screening and followed potentially by dermoscopic analysis, a biopsy and histopathological examination. Automated classification of skin lesions using images is a challenging task owing to the fine-grained variability in the appearance of skin lesions. Deep convolutional neural networks (CNNs) show potential for general and highly variable tasks across many fine-grained object categories. Here we demonstrate classification of skin lesions using a single CNN, trained end-to-end from images directly, using only pixels and disease labels as inputs. We train a CNN using a dataset of 129,450 clinical images—two orders of magnitude larger than previous datasets—consisting of 2,032 different diseases. We test its performance against 21 board-certified dermatologists on biopsy-proven clinical images with two critical binary classification use cases: keratinocyte carcinomas versus benign seborrheic keratoses; and malignant melanomas versus benign nevi. The first case represents the identification of the most common cancers, the second represents the identification of the deadliest skin cancer. The CNN achieves performance on par with all tested experts across both tasks, demonstrating an artificial intelligence capable of classifying skin cancer with a level of competence comparable to dermatologists. Outfitted with deep neural networks, mobile devices can potentially extend the reach of dermatologists outside of the clinic. It is projected that 6.3 billion smartphone subscriptions will exist by the year 2021 (ref. 13) and can therefore potentially provide low-cost universal access to vital diagnostic care.
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            The potential for artificial intelligence in healthcare

            The complexity and rise of data in healthcare means that artificial intelligence (AI) will increasingly be applied within the field. Several types of AI are already being employed by payers and providers of care, and life sciences companies. The key categories of applications involve diagnosis and treatment recommendations, patient engagement and adherence, and administrative activities. Although there are many instances in which AI can perform healthcare tasks as well or better than humans, implementation factors will prevent large-scale automation of healthcare professional jobs for a considerable period. Ethical issues in the application of AI to healthcare are also discussed.
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              The responsibility gap: Ascribing responsibility for the actions of learning automata

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                Author and article information

                Journal
                Indian J Dermatol
                Indian J Dermatol
                IJD
                Indian Journal of Dermatology
                Wolters Kluwer - Medknow (India )
                0019-5154
                1998-3611
                Sep-Oct 2020
                : 65
                : 5
                : 358-364
                Affiliations
                [1] From the Department of Mathematics, Occidental College, Los Angeles, USA
                [1 ] Systems Biotechnology Group, Technical University of Munich, Boltzmannstr. 15, Garching, Germany
                [2 ] Department of Geography, University of California, Santa Barbara, Newport Beach, CA, USA
                [3 ] Technology Department, Retirement Solutions Division, Pacific Life, Newport Beach, CA, USA
                Author notes
                Address for correspondence: Dr. Treena Basu, Department of Mathematics, Occidental College, 1600 Campus Road, Los Angeles, USA. E-mail: basu@ 123456oxy.edu Dr. Olaf Menzer, Department of Geography, University of California, Santa Barbara, California, USA. E-mail: menzer@ 123456geog.ucsb.edu
                Article
                IJD-65-358
                10.4103/ijd.IJD_419_20
                7640783
                33165392
                7c0c0a91-5ca8-450f-913c-6a769f1b8e32
                Copyright: © 2020 Indian Journal of Dermatology

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : May 2020
                : May 2020
                Categories
                Ijd® Symposium

                Dermatology
                best practices,ethics,electronic health records,machine learning
                Dermatology
                best practices, ethics, electronic health records, machine learning

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