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      Glymphatic dysfunction correlates with severity of small vessel disease and cognitive impairment in cerebral amyloid angiopathy.

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          Abstract

          Cerebral amyloid angiopathy (CAA) is characterized by β-amyloid deposition in cortical and leptomeningeal arterioles, which might result from glymphatic dysfunction. The aim was to explore glymphatic function in CAA using the non-invasive diffusion tensor image analysis along the perivascular space method.

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          Author and article information

          Journal
          Eur J Neurol
          European journal of neurology
          Wiley
          1468-1331
          1351-5101
          Oct 2022
          : 29
          : 10
          Affiliations
          [1 ] Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
          [2 ] Hefei National Lab for Physical Sciences at the Microscale and the Centers for Biomedical Engineering, University of Science and Technology of China, Hefei, China.
          [3 ] State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.
          Article
          10.1111/ene.15450
          35712978
          7c103e90-5690-4aef-b936-a4d9a1e202f3
          History

          glymphatic system,diffusion tensor imaging,cognitive function,cerebral small vessel disease neuroimaging markers,cerebral amyloid angiopathy

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