+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Mesenteric Arcade Arteries Contribute Substantially to Vascular Resistance in Conscious Rats

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          This paper describes a new technique for determining the intravascular pressure at the base of mesenteric arcades (arterial diameter less than 200 µm) in conscious, unrestrained, resting rats, using this technique we found that under Brietal anaesthesia, shortly after implanting the catheters, the pressure in the base of the arcades (P<sub>mes</sub>) was 86% of systemic pressure (P<sub>sys</sub>). After recovering from the anaesthetic, 6-8 h later, while P<sub>sys</sub> rose from average 79 to 114.5 mm Hg, P<sub>mes</sub> /P<sub>sys</sub> fell to 69%. By contrast, when anaesthesia was induced, although P<sub>sys</sub> immediately fell by 44%, P<sub>mes</sub>/P<sub>sys</sub> did not change. Acute pharmacological experiments in resting animals showed that the relative contribution of the arcade vessels to the peripheral resistance was variable. When serotonin was injected into the aorta, although P<sub>sys</sub> was unaffected, P<sub>mes</sub>/P<sub>sys</sub> fell from 67 to 27%. Conversely, with noradrenaline, P<sub>sys</sub> rose by 30%, but P<sub>mes</sub>/P<sub>sys </sub>remained unchanged. Angiotensin-II showed a third pattern, where P<sub>sys</sub> increased by 38%, but P<sub>mes</sub>/P<sub>sys</sub> rose transiently to 86%. The data suggest that in the rat mesenteric bed, under conscious conditions, the arcade arteries can contribute substantially to the control of peripheral resistance.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 30
          : 2
          : 73-79
          The Institute of Pharmacology and Danish Biomembrane Research Centre, Aarhus, Denmark
          158978 J Vasc Res 1993;30:73–79
          © 1993 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Research Paper


          Comment on this article