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      Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

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          Abstract

          Activation of adipose tissue inflammation is associated with obesity caused by lipid accumulation in adipocytes. Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive protein (CRP) seem to influence metabolic disorders. The present study evaluated whether polymorphisms in the CRP (rs1205) and IL-6 (rs1800795, rs2069845) genes are associated with the development of metabolic disorders in children and adolescents. A cross-sectional study was performed, consisting of 470 students from the municipality of Santa Cruz do Sul, Brazil, aged 7-17 years. Body mass index (BMI) was classified according to overweight and obesity. Genotyping was performed by real-time Polymerase Chain Reaction(PCR). Anthropometric characteristics, biochemical markers, immunological markers and blood pressure were assessed. Descriptive statistics, chi-square and logistic regression were used for the analyses. No association was detected between the rs1800795 polymorphism and the assessed variables. Individuals with the risk genotype in the rs1205 gene were associated with the risk of developing hypercholesterolemia (OR 2.79; CI 1.40, 5.57; p = 0.003). Carriers of the risk genotype in the rs2069845 gene are associated with the risk of developing obesity (OR 3.07; CI 1.08, 8.72; p = 0.03). The polymorphism rs2069845 was associated with obesity and rs1205 was associated with the risk of developing hypercholesterolemia in Brazilian schoolchildren.

          Translated abstract

          A ativação da inflamação do tecido adiposo está relacionada com a obesidade, causada pelo acúmulo de lipídios nos adipócitos. Através dessa ativação, citocinas pró-inflamatórias como Interleucina-6 (IL-6) e Proteína C-Reativa (CRP) parecem influenciar as desordens metabólicas. O presente estudo avaliou se polimorfis mos nos genes da CRP(rs1205) e da IL-6(rs1800795 rs2069845) estão relacionados com o desenvolvimento de alterações metabólicas em crianças e adolescentes. Estudo transversal, foi feito com 470 escolares do município de Santa Cruz do Sul, Brasil, com idades entre 7 a 17 anos. O índice de massa corporal (IMC) foi classificado de acordo com sobrepeso e obesidade. A genotipagem foi realizada através da Reação em Cadeia de Polimerase (PCR)em tempo real. Características antropométricas, indicadores bioquímicos, marcadores imunológicos e a pressão arterial foram avaliados. Estatísticas descritivas, qui-quadrado e regressão logística foram utilizadas para as análises. Nenhuma associação foi detectada entre o polimorfismo rs1800795 e as variáveis avaliadas. Indivíduos com o genótipo de risco no gene rs1205 foram associados ao risco de desenvolver hipercolesterolemia (OR = 2,79; IC: 1,40, 5,57; p= 0,003). Portadores do genótipo de risco no gene rs2069845 estão associados com o risco de desenvolver obesidade (OR = 3,07; IC: 1,08, 8,72; p= 0,03). O polimorfismo rs2069845 foi relacionado com obesidade e o rs1205 associado ao risco de desen volver hipercolesterolemia em escolares brasileiros.

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          Most cited references 65

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          Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

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            Inflammation and insulin resistance.

            Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. Together with the discovery of an important role for tissue macrophages, these new findings are helping to reshape thinking about how obesity increases the risk for developing T2D and the metabolic syndrome. The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.
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              Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association.

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                aabc
                Anais da Academia Brasileira de Ciências
                An. Acad. Bras. Ciênc.
                Academia Brasileira de Ciências (Rio de Janeiro )
                1678-2690
                June 2015
                : 87
                : 2
                : 915-924
                Affiliations
                [1 ] Universidade de Santa Cruz do Sul Brazil
                [2 ] Universidade de Santa Cruz do Sul Brazil
                [3 ] Universidade de Santa Cruz do Sul Brazil
                [4 ] Universidade de Santa Cruz do Sul Brazil
                [5 ] Universidade de Santa Cruz do Sul Brazil
                Article
                S0001-37652015000200915
                10.1590/0001-3765201520140364

                http://creativecommons.org/licenses/by/4.0/

                Product
                Product Information: SciELO Brazil
                Categories
                MULTIDISCIPLINARY SCIENCES

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