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      Future directions in the treatment of osteosarcoma.

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          Abstract

          Overall survival rates for osteosarcoma have remained essentially unchanged over the past 3 decades despite attempts to improve outcome via dose intensification and modification based on response. This review describes recent findings from contemporary clinical trials, advances in the comprehension of osteosarcoma biology and genomic complexity, and potential opportunities using targeted and immune-mediated therapies.

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          Author and article information

          Journal
          Curr. Opin. Pediatr.
          Current opinion in pediatrics
          Ovid Technologies (Wolters Kluwer Health)
          1531-698X
          1040-8703
          Feb 2016
          : 28
          : 1
          Affiliations
          [1 ] aDepartment of Oncology, St. Jude Children's Research Hospital bDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee cDana-Farber Cancer Institute, Boston, Massachusetts dDivision of Pediatric Hematology/Oncology, The Children's Hospital At Montefiore, Bronx, New York, USA.
          Article
          NIHMS752279
          10.1097/MOP.0000000000000298
          4761449
          26626558

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