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      Alopecia areata: a new treatment plan

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          Abstract

          Many therapeutic modalities have been used to treat alopecia areata, with variable efficacy and safety profiles. Unfortunately, none of these agents is curative or preventive. Also, many of these therapeutic agents have not been subjected to randomized, controlled trials, and, except for topical immunotherapy, there are few published studies on long-term outcomes. The treatment plan is designed according to the patient’s age and extent of disease. In this paper, the therapeutic agents are organized according to their efficacy and safety profiles into first-line, second-line, and third-line options.

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          Most cited references115

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          Alopecia areata update: part II. Treatment.

          Various therapeutic agents have been described for the treatment of alopecia areata (AA), but none are curative or preventive. The aim of AA treatment is to suppress the activity of the disease. The high rate of spontaneous remission and the paucity of randomized, double-blind, placebo-controlled studies make the evidence-based assessment of these therapies difficult. The second part of this two-part series on AA discusses treatment options in detail and suggests treatment plans according to specific disease presentation. It also reviews recently reported experimental treatment options and potential directions for future disease management. After completing this learning activity, participants should be able to compare the efficacy and safety of various treatment options, formulate a treatment plan tailored to individual patients, and recognize recently described treatments and potential therapeutic approaches. Copyright (c) 2009 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
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            Alopecia areata update.

            Alopecia areata (AA) is a nonscarring hair loss condition. Among the many factors under investigation in the pathogenesis of AA, the main areas of concentration have been genetic constitution as well as nonspecific immune and organ-specific autoimmune reactions. Treatment with intralesional corticosteroid injections for localized patchy AA and topical immunotherapy for extensive AA have proven successful in the majority of patients, although all treatments are palliative and do not change the prognosis of the disease.
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              Alopecia areata.

              Alopecia areata (AA) is a nonscarring, autoimmune, inflammatory, hair loss on the scalp, and/or body. Etiology and pathogenesis are still unknown. The most common site affected is the scalp. Histopathology is characterized by an increased number of the catagen and telogen follicles, the presence of inflammatory lymphocytic infiltrate in the peribulbar region ("swarm of bees"). Corticosteroids are the most popular drugs for the treatment of this disease. Etiologic and pathogenic mechanisms, as well as other current treatments available will be discussed in this article.
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                Author and article information

                Journal
                Clin Cosmet Investig Dermatol
                Clinical, Cosmetic and Investigational Dermatology
                Clinical, Cosmetic and Investigational Dermatology
                Dove Medical Press
                1178-7015
                2011
                22 July 2011
                : 4
                : 107-115
                Affiliations
                Department of Dermatology, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia
                Author notes
                Correspondence: Adel Alsantali, Hair Disorders Unit, Department of Dermatology, King Fahd Armed Forces, Hospital, PO Box 5389, 3 Jeddah 21593, Saudi Arabia, Tel +966 2 6653000 Ext 2668, Fax +966 2 6638936, Email santli26@ 123456hotmail.com
                Article
                ccid-4-107
                10.2147/CCID.S22767
                3149478
                21833161
                7c3c6629-75c2-4649-886d-b348748a501c
                © 2011 Alsantali, publisher and licensee Dove Medical Press Ltd.

                This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

                History
                Categories
                Review

                Dermatology
                alopecia areata,corticosteroids,immunotherapy,intralesional,phototherapy,sulfasalazine
                Dermatology
                alopecia areata, corticosteroids, immunotherapy, intralesional, phototherapy, sulfasalazine

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