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      Impaired sleep quality is associated with concurrent elevations in inflammatory markers: are post-menopausal women at greater risk?

      research-article
      1 , 2 , , 2
      Biology of Sex Differences
      BioMed Central
      Sleep, C-reactive protein, TNF-α, IL-6, Sex, Menopause

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          Abstract

          Abstract
          Background

          Chronic inflammation and impaired sleep increase the risk for cardiovascular disease. Menopausal women may be particularly at risk as a result of impaired sleep. The objective of the current investigation was to assess the relationship between poor sleep and C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and myeloperoxidase (MPO) in healthy non- and postmenopausal women and men.

          Methods

          A fasting blood draw was obtained from 122 healthy men and women (31 were postmenopausal). Higher scores on the Pittsburgh Sleep Quality Index (PSQI) were used to define poor sleep. Given the sample size and healthy nature of the sample, hierarchical linear regression analyses were performed on a composite inflammatory score involving CRP, IL-6, and TNF-α. Sex/menopausal group and PSQI were entered as predictors, and the interaction of the group by PSQI was entered stepwise. Analyses on MPO were performed separately.

          Results

          Sleep quality was associated with higher inflammatory activity ( β = 0.272, P = 0.003), which remained significant ( P = 0.046) after controlling for age, waist circumference, exercise times per week, and depressive symptoms . While in the same direction, sleep quality was not significantly associated with MPO. Dichotomizing sleep quality led to similar results.

          Conclusion

          Impaired sleep quality is independently associated with greater inflammation in healthy adult men and women. Despite an overall less favorable metabolic and inflammatory profile in postmenopausal women, impaired sleep did not emerge as differentially related to inflammatory activity in this group.

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          Most cited references69

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          Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.

          We sought to investigate the effects of sleep loss on high-sensitivity C-reactive protein (CRP) levels. Concentrations of high-sensitivity CRP are predictive of future cardiovascular morbidity. In epidemiologic studies, short sleep duration and sleep complaints have also been associated with increased cardiovascular morbidity. Two studies were undertaken to examine the effect of acute total and short-term partial sleep deprivation on concentrations of high-sensitivity CRP in healthy human subjects. In Experiment 1, 10 healthy adult subjects stayed awake for 88 continuous hours. Samples of high-sensitivity CRP were collected every 90 min for 5 consecutive days, encompassing the vigil. In Experiment 2, 10 subjects were randomly assigned to either 8.2 h (control) or 4.2 h (partial sleep deprivation) of nighttime sleep for 10 consecutive days. Hourly samples of high-sensitivity CRP were taken during a baseline night and on day 10 of the study protocol. The CRP concentrations increased during both total and partial sleep deprivation conditions, but remained stable in the control condition. Systolic blood pressure increased across deprivation in Experiment 1, and heart rate increased in Experiment 2. Both acute total and short-term partial sleep deprivation resulted in elevated high-sensitivity CRP concentrations, a stable marker of inflammation that has been shown to be predictive of cardiovascular morbidity. We propose that sleep loss may be one of the ways that inflammatory processes are activated and contribute to the association of sleep complaints, short sleep duration, and cardiovascular morbidity observed in epidemiologic surveys.
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            Depression and Coronary Heart Disease

            Circulation, 118(17), 1768-1775
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              A prospective study of sleep duration and coronary heart disease in women.

              Long-term sleep deprivation is common in today's society. Recent experiments have demonstrated that short-term sleep deprivation in healthy subjects results in adverse physiologic changes, including a decreased glucose tolerance and an increased blood pressure. However, the long-term health consequences of long-term sleep deprivation are unclear. The objective of this study was to determine whether decreased sleep duration (from self-reports) is associated with an increased risk of coronary events. We studied a cohort of 71 617 US female health professionals (aged 45-65 years), without reported coronary heart disease (CHD) at baseline, who were enrolled in the Nurses' Health Study. Subjects were mailed a questionnaire in 1986 asking about daily sleep duration. Subjects were followed up until June 30, 1996, for the occurrence of CHD-related events. We assessed the relationship between self-reported sleep duration and incident CHD. A total of 934 coronary events were documented (271 fatal and 663 nonfatal) during the 10 years of follow up. Age-adjusted relative risks (95% confidence intervals) of CHD (with 8 hours of daily sleep being considered the reference group) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.82 (1.34-2.41), 1.30 (1.08-1.57), and 1.06 (0.89-1.26), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.57 (1.18-2.11). After adjusting for various potential confounders, including snoring, body mass index, and smoking, the relative risks of CHD (95% confidence intervals) for individuals reporting 5 or fewer, 6, and 7 hours of sleep were 1.45 (1.10-1.92), 1.18 (0.98-1.42), and 1.09 (0.91-1.30), respectively. The relative risk (95% confidence interval) for 9 or more hours of sleep was 1.38 (1.03-1.86). Short and long self-reported sleep durations are independently associated with a modestly increased risk of coronary events.
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                Author and article information

                Contributors
                (514) 376-3330 , bianca.d.antono@umontreal.ca
                veronique.bouchard55@gmail.com
                Journal
                Biol Sex Differ
                Biol Sex Differ
                Biology of Sex Differences
                BioMed Central (London )
                2042-6410
                8 July 2019
                8 July 2019
                2019
                : 10
                : 34
                Affiliations
                [1 ]ISNI 0000 0000 8995 9090, GRID grid.482476.b, Research Center, , Montreal Heart Institute, ; 5000 Belanger Street, Montreal, Quebec, H1T 1C8 Canada
                [2 ]ISNI 0000 0001 2292 3357, GRID grid.14848.31, Psychology Department, , Université de Montréal, Montreal, ; Quebec, Canada
                Author information
                http://orcid.org/0000-0001-7907-5125
                Article
                250
                10.1186/s13293-019-0250-x
                6615113
                31287027
                7c3f88d4-b7f8-4c83-9764-8908a7f63611
                © The Author(s). 2019

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                : 8 May 2019
                : 30 June 2019
                Funding
                Funded by: Canadian Institutes of Health Research
                Award ID: 79456 & 111017
                Funded by: Montreal Heart Institute Foundation
                Award ID: -
                Categories
                Research
                Custom metadata
                © The Author(s) 2019

                Human biology
                sleep,c-reactive protein,tnf-α,il-6,sex,menopause
                Human biology
                sleep, c-reactive protein, tnf-α, il-6, sex, menopause

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