Ultra-pH-responsive split i-motif based aptamer anchoring strategy for specific activatable imaging of acidic tumor microenvironment.

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Abstract

A non-blocking split i-motif based aptamer anchoring strategy was developed as a general platform for sensing weakly acidic tumor microenvironment. By rationally tuning the response range to pH 7.0-6.4 and adjusting aptamer types, the strategy achieved specific, pHe-activated imaging of different cancers in vitro and in vivo.

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Journal

Journal ID (iso-abbrev): Chem. Commun. (Camb.)

Title: Chemical communications (Cambridge, England)

Publisher: Royal Society of Chemistry (RSC)

ISSN (Electronic): 1364-548X

ISSN (Print): 1359-7345

Publication date (Electronic): Sep 11 2018

Volume: 54

Issue: 73

Affiliations

[1 ] State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Hunan University, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Changsha, Hunan 410082, China. kmwang@hnu.edu.cn huishi_2009@hnu.edu.cn.

Article

DOI: 10.1039/c8cc04420a

PubMed ID: 30137061

SO-VID: 7c5a401c-b1d2-4ff7-a45f-4233745520b2

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