To evaluate the effectiveness and safety of lidocaine on postoperative quality of recovery and lung protection of patients undergoing thoracoscopic radical resection of lung cancer.
Seventy ASA II–III patients undergoing thoracoscopic radical resection of lung cancer were randomly assigned into either the lidocaine group (Group L) or control group (Group C). Patients in Group L received lidocaine with a 1.5 mg/kg bolus before induction of anesthesia, followed by 2.0 mg/kg/h until the end of the operation while the patients in Group C received volume-matched normal saline at the same rate. The main outcome was the quality of recovery-40 score (QoR-40 score) at 24 h postoperatively. The peak airway pressure (Ppeak) and plateau airway pressure (Pplat), the partial pressure of oxygen in arterial blood (PaO 2), partial pressure of carbon dioxide in arterial blood (PaCO 2), alveolar-arterial oxygen gradient (A-aDO2), oxygenation index (OI), time to first flatus and defecation, intraoperative hemodynamics and opioid consumption were also recorded.
There were no statistically difference at patients’ baseline characteristics. The QoR-40 score of Group L was significantly higher than that of Group C at 24 h after surgery ( P=0.014). Ppeak, Pplat, and A-aDO 2 of Group L were significantly lower than those of Group C ( P<0.001, P<0.001, P=0.025, respectively) after the ventilation recovery of both lungs, and the PaO 2 and OI of the Group L were significantly higher than those of Group C ( P=0.027, P=0.027, respectively). Time to first flatus and defecation in Group L was significantly lower compared with Group C ( P=0.037, P=0.025, respectively).