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      Lipid metabolism in Alzheimer’s disease

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          Abstract

          Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative diseases, such as Alzheimer’s disease (AD), and other central nervous system insults. The brain contains thousands of lipid species, but the complex lipid compositional diversity and the function of each of lipid species are currently poorly understood. This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis.

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          Author and article information

          Contributors
          liuq2012@ustc.edu.cn
          Journal
          Neurosci Bull
          Neurosci Bull
          Neuroscience Bulletin
          Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (Heidelberg )
          1673-7067
          1995-8218
          15 April 2014
          April 2014
          : 30
          : 2
          : 331-345
          Affiliations
          [1 ] GRID grid.59053.3a, ISNI 0000000121679639, CAS Key Laboratory of Brain Function and Disease and School of Life Sciences, , University of Science and Technology of China, ; Hefei, 230027 China
          [2 ] GRID grid.4367.6, ISNI 0000000123557002, Department of Genetics, , Washington University School of Medicine, ; St. Louis, MO 63011 USA
          Article
          PMC5562656 PMC5562656 5562656 1410
          10.1007/s12264-013-1410-3
          5562656
          24733655
          7c6039b7-8cbc-40be-9f4a-6cccda04c677
          © Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2014
          History
          : 22 December 2013
          : 25 February 2014
          Categories
          Review
          Custom metadata
          © Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2014

          brain aging,lipid metabolism,Alzheimer’s disease
          brain aging, lipid metabolism, Alzheimer’s disease

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