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      The practice of health risk assessment in the united states (1975–1995): How the U.S. and other countries can benefit from that experience

      Human and Ecological Risk Assessment: An International Journal

      Informa UK Limited

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          Most cited references 218

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          Uncertainty

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            Cell proliferation in carcinogenesis.

            Chemicals that induce cancer at high doses in animal bioassays often fail to fit the traditional characterization of genotoxins. Many of these nongenotoxic compounds (such as sodium saccharin) have in common the property that they increase cell proliferation in the target organ. A biologically based, computerized description of carcinogenesis was used to show that the increase in cell proliferation can account for the carcinogenicity of nongenotoxic compounds. The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation. Mechanistic information is required for determination of the existence of a threshold for the proliferative (and carcinogenic) response of nongenotoxic chemicals and the estimation of risk for human exposure.
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              Behavior Assessment Model for Trace Organics in Soil: I. Model Description1

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                Author and article information

                Journal
                Human and Ecological Risk Assessment: An International Journal
                Human and Ecological Risk Assessment: An International Journal
                Informa UK Limited
                1080-7039
                1549-7860
                March 1995
                March 1995
                : 1
                : 1
                : 29-79
                Article
                10.1080/10807039509379983
                © 1995

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