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Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

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      A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation ( SO 2 ) levels in phantom blood vessels with a range of blood flow speeds (0 to 17    mm / s ). A 50- μm-diameter blood vessel phantom is imaged, and SO 2 levels are measured using DWP-OCT and compared with values provided by a commercial oximeter at various blood oxygen concentrations. The influences of blood flow speed and mechanisms of SNR phase degradation on the accuracy of SO 2 measurement are identified and investigated.

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      Author and article information

      [a ]University of Texas at Austin , Departments of Electrical and Computer Engineering, 1 University Station C0803, Austin, Texas 78712
      [b ]University of Texas Health Science Center at San Antonio , Department of Ophthalmology, 7703 Floyd Curl Drive, San Antonio, Texas 78229
      [c ]University of Texas at Austin , Department of Biomedical Engineering, 1 University Station C0800, Austin, Texas 78712
      Author notes
      Address all correspondence to: Roman V. Kuranov, University of Texas Health Science Center at San Antonio, Department of Ophthalmology, 7703 Floyd Curl Drive, San Antonio, Texas 78229. Tel: 210-567-8402; Fax: 210-567-8413; E-mail: rkuranov@
      J Biomed Opt
      J Biomed Opt
      Journal of Biomedical Optics
      Society of Photo-Optical Instrumentation Engineers
      2 May 2013
      May 2013
      : 18
      : 5
      23640076 3642243 10.1117/1.JBO.18.5.056005 JBO-130033R 130033R
      © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
      Figures: 9, Tables: 0
      Funded by: NIH KL2
      Award ID: UL1RR025767
      Award ID: KL2RR025766
      Funded by: San Antonio Area Foundation
      Award ID: 130977
      Funded by: NIH
      Award ID: R01 EY018855
      Award ID: R01 EY014211
      Research Papers: Imaging
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      Yin et al.: Dual-wavelength photothermal optical coherence tomography for imaging…


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